4txk
From Proteopedia
(Difference between revisions)
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| - | ''' | + | ==Construct of MICAL-1 containing the monooxygenase and calponin homology domains== |
| - | + | <StructureSection load='4txk' size='340' side='right' caption='[[4txk]], [[Resolution|resolution]] 2.88Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[4txk]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4TXK OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4TXK FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene></td></tr> | |
| - | + | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4txi|4txi]]</td></tr> | |
| - | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4txk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4txk OCA], [http://pdbe.org/4txk PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4txk RCSB], [http://www.ebi.ac.uk/pdbsum/4txk PDBsum]</span></td></tr> | |
| - | [[Category: | + | </table> |
| - | [[Category: Bianchet, M | + | == Function == |
| - | [[Category: | + | [[http://www.uniprot.org/uniprot/MICA1_MOUSE MICA1_MOUSE]] Monooxygenase that promotes depolymerization of F-actin by mediating oxidation of specific methionine residues on actin. Acts by modifying actin subunits through the addition of oxygen to form methionine-sulfoxide, leading to promote actin filament severing and prevent repolymerization. Acts as a cytoskeletal regulator that connects NEDD9 to intermediate filaments (By similarity). Also acts as a negative regulator of apoptosis via its interaction with STK38 and STK38L; acts by antagonizing STK38 and STK38L activation by MST1/STK4. |
| - | [[Category: | + | __TOC__ |
| + | </StructureSection> | ||
| + | [[Category: Alqassim, S S]] | ||
| + | [[Category: Amzel, L M]] | ||
| + | [[Category: Bianchet, M A]] | ||
| + | [[Category: Calponin homology]] | ||
| + | [[Category: Mical]] | ||
| + | [[Category: Monooyxgenase]] | ||
| + | [[Category: Oxidoreductase]] | ||
Revision as of 12:44, 23 December 2015
Construct of MICAL-1 containing the monooxygenase and calponin homology domains
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