4zhn

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'''Unreleased structure'''
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==Crystal Structure of AlkB T208A mutant protein in complex with Co(II), 2-oxoglutarate, and methylated trinucleotide T-meA-T==
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<StructureSection load='4zhn' size='340' side='right' caption='[[4zhn]], [[Resolution|resolution]] 1.33&Aring;' scene=''>
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The entry 4zhn is ON HOLD
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== Structural highlights ==
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<table><tr><td colspan='2'>[[4zhn]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ZHN OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ZHN FirstGlance]. <br>
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Authors: Ergel, B., Yu, B., Vorobiev, S.M., Forouhar, F., Hunt, J.F., Northeast Structural Genomics Consortium (NESG)
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=AKG:2-OXOGLUTARIC+ACID'>AKG</scene>, <scene name='pdbligand=CO:COBALT+(II)+ION'>CO</scene></td></tr>
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<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MA7:1N-METHYLADENOSINE-5-MONOPHOSPHATE'>MA7</scene></td></tr>
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Description:
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/DNA_oxidative_demethylase DNA oxidative demethylase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.14.11.33 1.14.11.33] </span></td></tr>
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[[Category: Unreleased Structures]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4zhn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4zhn OCA], [http://pdbe.org/4zhn PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4zhn RCSB], [http://www.ebi.ac.uk/pdbsum/4zhn PDBsum]</span></td></tr>
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[[Category: Forouhar, F]]
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</table>
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== Function ==
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[[http://www.uniprot.org/uniprot/ALKB_ECOLI ALKB_ECOLI]] Dioxygenase that repairs alkylated DNA and RNA containing 3-methylcytosine or 1-methyladenine by oxidative demethylation. Has highest activity towards 3-methylcytosine. Has lower activity towards alkylated DNA containing ethenoadenine, and no detectable activity towards 1-methylguanine or 3-methylthymine. Accepts double-stranded and single-stranded substrates. Requires molecular oxygen, alpha-ketoglutarate and iron. Provides extensive resistance to alkylating agents such as MMS and DMS (SN2 agents), but not to MMNG and MNU (SN1 agents).<ref>PMID:12226668</ref> <ref>PMID:12594517</ref> <ref>PMID:16482161</ref> <ref>PMID:19706517</ref> <ref>PMID:21068844</ref> <ref>PMID:20084272</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: DNA oxidative demethylase]]
[[Category: Ergel, B]]
[[Category: Ergel, B]]
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[[Category: Vorobiev, S.M]]
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[[Category: Forouhar, F]]
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[[Category: Hunt, J.F]]
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[[Category: Hunt, J F]]
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[[Category: Structural genomic]]
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[[Category: Vorobiev, S M]]
[[Category: Yu, B]]
[[Category: Yu, B]]
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[[Category: Northeast Structural Genomics Consortium (Nesg)]]
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[[Category: Beta jellyroll]]
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[[Category: Dna repair enzyme]]
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[[Category: Nesg]]
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[[Category: Oxidoreductase-dna complex]]
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[[Category: PSI, Protein structure initiative]]

Revision as of 12:47, 23 December 2015

Crystal Structure of AlkB T208A mutant protein in complex with Co(II), 2-oxoglutarate, and methylated trinucleotide T-meA-T

4zhn, resolution 1.33Å

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