5d14
From Proteopedia
(Difference between revisions)
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| - | ''' | + | ==The atomic resolution crystal structure of human IL-8== |
| - | + | <StructureSection load='5d14' size='340' side='right' caption='[[5d14]], [[Resolution|resolution]] 1.00Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[5d14]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5D14 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5D14 FirstGlance]. <br> | |
| - | + | </td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4xdx|4xdx]]</td></tr> | |
| - | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5d14 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5d14 OCA], [http://pdbe.org/5d14 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5d14 RCSB], [http://www.ebi.ac.uk/pdbsum/5d14 PDBsum]</span></td></tr> | |
| - | + | </table> | |
| - | [[ | + | == Function == |
| + | [[http://www.uniprot.org/uniprot/IL8_HUMAN IL8_HUMAN]] IL-8 is a chemotactic factor that attracts neutrophils, basophils, and T-cells, but not monocytes. It is also involved in neutrophil activation. It is released from several cell types in response to an inflammatory stimulus. IL-8(6-77) has a 5-10-fold higher activity on neutrophil activation, IL-8(5-77) has increased activity on neutrophil activation and IL-8(7-77) has a higher affinity to receptors CXCR1 and CXCR2 as compared to IL-8(1-77), respectively.<ref>PMID:2145175</ref> <ref>PMID:2212672</ref> <ref>PMID:11978786</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
[[Category: Brzezinski, K]] | [[Category: Brzezinski, K]] | ||
| - | [[Category: Pompeu, Y]] | ||
| - | [[Category: Lu, S]] | ||
[[Category: Jakoncic, J]] | [[Category: Jakoncic, J]] | ||
| - | [[Category: Ostrov, D | + | [[Category: Lu, S]] |
| + | [[Category: Ostrov, D A]] | ||
| + | [[Category: Pompeu, Y]] | ||
| + | [[Category: Chemokine]] | ||
| + | [[Category: Cytokine]] | ||
| + | [[Category: Il8-like fold]] | ||
| + | [[Category: Immune system]] | ||
| + | [[Category: Inflammation]] | ||
Revision as of 12:48, 23 December 2015
The atomic resolution crystal structure of human IL-8
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Categories: Brzezinski, K | Jakoncic, J | Lu, S | Ostrov, D A | Pompeu, Y | Chemokine | Cytokine | Il8-like fold | Immune system | Inflammation
