DNA adenine methylase

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<StructureSection load='4rtn' size='340' side='right' caption='E. coli DNA adenine metylase complex with SAH and DNA (PDB code [[4rtn]])' scene=''>
<StructureSection load='4rtn' size='340' side='right' caption='E. coli DNA adenine metylase complex with SAH and DNA (PDB code [[4rtn]])' scene=''>
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'''DNA adenine methylase''' (DAM) adds a methyl group to adenines in the DNA sequence GATC. The daughter strand remains unmethylated for a short while during which mismatch repair of DNA can take place. DAM has a role in regulation of replication by delaying the availability of the origin of replication to activation during the cell cycle. The origin of replication in E. coli contains 11 GATC sequences. In E. coli, downstream GATC sequences are methylated to promote RNA transcription. DAM uses S-adenosyl-L-homocysteine (AdoHcy, SAH) as methyl donor.<ref>PMID:16959970</ref>
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'''DNA adenine methylase''' (DAM) adds a methyl group to adenines in the DNA sequence GATC. The daughter strand remains unmethylated for a short while during which mismatch repair of DNA can take place. DAM has a role in regulation of replication by delaying the availability of the origin of replication to activation during the cell cycle. The origin of replication in E. coli contains 11 GATC sequences. In E. coli, downstream GATC sequences are methylated to promote RNA transcription. DAM uses S-adenosyl-L-homocysteine (AdoHcy, SAH) as methyl donor.<ref>PMID:15802246</ref>
== Function ==
== Function ==

Revision as of 14:16, 30 December 2015

E. coli DNA adenine metylase complex with SAH and DNA (PDB code 4rtn)

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3D Structures of DNA adenine methylase

Updated on 30-December-2015

1q0s – T4DAM + SAH – Enterobacter phage T4
1q0t, 1yf3, 1yfj – T4DAM + SAH + DNA
1yfl – T4DAM + sinefungin + DNA
2g1p, 4rtk, 4rtn, 4rtq – EcDAM + SAH + DNA – Escherichia coli
2ore, 4gbe – EcDAM + SAH
4gol, 4gom, 4gon, 4goo – EcDAM + Aza-SAM derivative
4rtj, 4rtl, 4rto – EcDAM + sinefungin + DNA
4rtm, 4rtp, 4rtr, 4rts – EcDAM + AdoMet + DNA

References

  1. ↑ Lobner-Olesen A, Skovgaard O, Marinus MG. Dam methylation: coordinating cellular processes. Curr Opin Microbiol. 2005 Apr;8(2):154-60. PMID:15802246 doi:http://dx.doi.org/10.1016/j.mib.2005.02.009

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Michal Harel, Alexander Berchansky, Joel L. Sussman

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