5azf

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'''Unreleased structure'''
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==Crystal structure of LGG-1 complexed with a WEEL peptide==
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<StructureSection load='5azf' size='340' side='right' caption='[[5azf]], [[Resolution|resolution]] 1.60&Aring;' scene=''>
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The entry 5azf is ON HOLD until Paper Publication
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== Structural highlights ==
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<table><tr><td colspan='2'>[[5azf]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5AZF OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5AZF FirstGlance]. <br>
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Authors: Watanabe, Y., Noda, N.N.
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CD:CADMIUM+ION'>CD</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5azg|5azg]], [[5azh|5azh]]</td></tr>
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Description:
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5azf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5azf OCA], [http://pdbe.org/5azf PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5azf RCSB], [http://www.ebi.ac.uk/pdbsum/5azf PDBsum]</span></td></tr>
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[[Category: Unreleased Structures]]
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</table>
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== Function ==
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[[http://www.uniprot.org/uniprot/LGG1_CAEEL LGG1_CAEEL]] Ubiquitin-like modifier involved in autophagy and essential for dauer development and life-span extension (PubMed:12958363, PubMed:20523114). Plays a role in mitophagy (PubMed:25896323).<ref>PMID:12958363</ref> <ref>PMID:20523114</ref> <ref>PMID:25896323</ref> [[http://www.uniprot.org/uniprot/ATG19_YEAST ATG19_YEAST]] Cargo-receptor protein involved in the cytoplasm to vacuole transport (Cvt) and in autophagy. Recognizes cargo proteins, such as APE4, LAP3, LAP4 and AMS1 and delivers them to the pre-autophagosomal structure for eventual engulfment by the autophagosome and targeting to the vacuole. Involved in the organization of the preautophagosomal structure (PAS). ATG19 association with cargo protein is required to localize ATG11 to the PAS. Also involved in endoplasmic reticulum-specific autophagic process, in selective removal of ER-associated degradation (ERAD) substrates, and is essential for the survival of cells subjected to severe ER stress. Plays also a role in regulation of filamentous growth.<ref>PMID:11382752</ref> <ref>PMID:11430817</ref> <ref>PMID:12479807</ref> <ref>PMID:12479808</ref> <ref>PMID:15138258</ref> <ref>PMID:15801807</ref> <ref>PMID:16186126</ref> <ref>PMID:15659643</ref> <ref>PMID:17132049</ref> <ref>PMID:17700056</ref> <ref>PMID:17192412</ref> <ref>PMID:17238920</ref> <ref>PMID:19061865</ref> <ref>PMID:21228276</ref> <ref>PMID:19021777</ref> <ref>PMID:20659891</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Noda, N N]]
[[Category: Watanabe, Y]]
[[Category: Watanabe, Y]]
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[[Category: Noda, N.N]]
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[[Category: Autophagy]]
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[[Category: Protein binding]]
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[[Category: Ubiquitin-like]]

Revision as of 19:36, 30 December 2015

Crystal structure of LGG-1 complexed with a WEEL peptide

5azf, resolution 1.60Å

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