DNA methyltransferase

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
{{STRUCTURE_1qnt| PDB=1qnt | SIZE=400| SCENE= |right|CAPTION=Human O6-methylguanine DNA methyltransferase, [[1qnt]] }}
{{STRUCTURE_1qnt| PDB=1qnt | SIZE=400| SCENE= |right|CAPTION=Human O6-methylguanine DNA methyltransferase, [[1qnt]] }}
-
'''DNA methyltransferase''' (DNMT) catalyzes the transfer of methyl group to DNA. DNMT uses S-adenosyl methionine (SAM) as the methyl donor. The SAM analog S-adenosyl homocysteine (SAH) is a powerful inhibitor of DNMT.<ref>PMID:8127644</ref>
+
'''DNA methyltransferase''' (DNMT) catalyzes the transfer of methyl group to DNA. Methylation is essential for gene expression. DNMT uses S-adenosyl methionine (SAM) as the methyl donor. The SAM analog S-adenosyl homocysteine (SAH) is a powerful inhibitor of DNMT.
 +
 
 +
*'''Methylguanine DNMT''' repairs the DNA lesion O<sup>6</sup>-methylguanine to guanine.<ref>PMID:17485253</ref><br />
 +
*'''Methylcytosine DNMT''' methylates the 5 position of cytosine. <ref>PMID:8127644</ref><br />
 +
*'''Methyladenine DNMT''' methylates the 6 position of adenine. <ref>PMID:12732637</ref><br />
 +
 
 +
== Relevance ==
 +
 
 +
DNMT inhibitors are being tested in cancer therapy.
 +
 
 +
== Disease ==
 +
 
 +
The human ICF disorder is caused by mutations in DNMT 3B.
== 3D Structures of DNA methyltransferase ==
== 3D Structures of DNA methyltransferase ==

Revision as of 14:17, 31 December 2015

Template:STRUCTURE 1qnt

DNA methyltransferase (DNMT) catalyzes the transfer of methyl group to DNA. Methylation is essential for gene expression. DNMT uses S-adenosyl methionine (SAM) as the methyl donor. The SAM analog S-adenosyl homocysteine (SAH) is a powerful inhibitor of DNMT.

  • Methylguanine DNMT repairs the DNA lesion O6-methylguanine to guanine.[1]
  • Methylcytosine DNMT methylates the 5 position of cytosine. [2]
  • Methyladenine DNMT methylates the 6 position of adenine. [3]

Contents

Relevance

DNMT inhibitors are being tested in cancer therapy.

Disease

The human ICF disorder is caused by mutations in DNMT 3B.

3D Structures of DNA methyltransferase

Updated on 31-December-2015

References

  1. ↑ Kaina B, Christmann M, Naumann S, Roos WP. MGMT: key node in the battle against genotoxicity, carcinogenicity and apoptosis induced by alkylating agents. DNA Repair (Amst). 2007 Aug 1;6(8):1079-99. Epub 2007 May 7. PMID:17485253 doi:http://dx.doi.org/10.1016/j.dnarep.2007.03.008
  2. ↑ Kumar S, Cheng X, Klimasauskas S, Mi S, Posfai J, Roberts RJ, Wilson GG. The DNA (cytosine-5) methyltransferases. Nucleic Acids Res. 1994 Jan 11;22(1):1-10. PMID:8127644
  3. ↑ Thomas CB, Scavetta RD, Gumport RI, Churchill ME. Structures of liganded and unliganded RsrI N6-adenine DNA methyltransferase: a distinct orientation for active cofactor binding. J Biol Chem. 2003 Jul 11;278(28):26094-101. Epub 2003 May 4. PMID:12732637 doi:http://dx.doi.org/10.1074/jbc.M303751200

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky

Retrieved from "http://52.214.119.220/wiki/index.php/DNA_methyltransferase"
Personal tools