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Diphtheria toxin

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<StructureSection load='1ddt' size='350' side='right' caption='Structure of diphtheria toxin complex with adenylyl-UMP (PDB code [[1ddt]]).' scene='59/592684/Cv/1'>
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<StructureSection load='1ddt' size='350' side='right' caption='Structure of diphtheria toxin complex with adenylyl-UMP (PDB code [[1ddt]]).' scene='59/592684/Cv/4'>
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__TOC__
== Function ==
== Function ==
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== Structural highlights ==
== Structural highlights ==
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DT is proteolitically cleaved into 2 fragments. Fragment A contains the <scene name='59/592684/Cv/3'>catalytic domain (C)</scene> and fragment B contains the transmembrane (T) and receptor-binding (R) domains. DT active site is located in a cleft in the C domain.<ref>PMID:7833807</ref> The 2 monomers of DT interact by domain swapping to form a compact, globular dimer structure.
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<scene name='59/592684/Cv/6'>The biological assembly of Diphtheria toxin is dimer</scene>. DT is proteolitically cleaved into 2 fragments. Fragment A contains the <scene name='59/592684/Cv/3'>catalytic domain (C)</scene> and fragment B contains the transmembrane (T) and receptor-binding (R) domains. DT active site is located in a cleft in the C domain.<ref>PMID:7833807</ref> The 2 monomers of DT interact by domain swapping to form a compact, globular dimer structure.
</StructureSection>
</StructureSection>

Revision as of 15:51, 3 January 2016

Structure of diphtheria toxin complex with adenylyl-UMP (PDB code 1ddt).

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3D structures of diphtheria toxin

Updated on 03-January-2016

References

  1. ↑ Pappenheimer AM Jr. Diphtheria toxin. Annu Rev Biochem. 1977;46:69-94. PMID:20040 doi:http://dx.doi.org/10.1146/annurev.bi.46.070177.000441
  2. ↑ Bennett MJ, Choe S, Eisenberg D. Refined structure of dimeric diphtheria toxin at 2.0 A resolution. Protein Sci. 1994 Sep;3(9):1444-63. PMID:7833807

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Michal Harel, Alexander Berchansky, Joel L. Sussman

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