Botulinum neurotoxin
From Proteopedia
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'''Botulinum neurotoxin''' (CBN) is produced by the bacterium ''Clostridium botulinum''. CBP contains a light (residues 1-440) and a heavy (residues 441-875) chains (LC and HC). CBP LC proteolyzes SNARE substrates which are essential for synaptic vescicle fusion and neurotransmitter release thus causing paralysis. CBP HC acts as a channel and as transmembrane chaperone enabling the passage of the LC into the cytosol. <ref>PMID:15907915</ref> The bacteria produces 8 neurotoxins which differ in their antigens.<br /> | '''Botulinum neurotoxin''' (CBN) is produced by the bacterium ''Clostridium botulinum''. CBP contains a light (residues 1-440) and a heavy (residues 441-875) chains (LC and HC). CBP LC proteolyzes SNARE substrates which are essential for synaptic vescicle fusion and neurotransmitter release thus causing paralysis. CBP HC acts as a channel and as transmembrane chaperone enabling the passage of the LC into the cytosol. <ref>PMID:15907915</ref> The bacteria produces 8 neurotoxins which differ in their antigens.<br /> | ||
| - | *'''Botulinum neurotoxin type A''' is the potent disease agent in botulism.<br /> | + | *'''Botulinum neurotoxin type A''' is the potent disease agent in botulism. See [[Clostridium botulinum neurotoxin serotype A light chain]].<br /> |
*'''Botulinum neurotoxin type B''' is used for treatment of severe spasms in the neck muscles. See [[Clostridium Botulinum Neurotoxin Type B]]. <br /> | *'''Botulinum neurotoxin type B''' is used for treatment of severe spasms in the neck muscles. See [[Clostridium Botulinum Neurotoxin Type B]]. <br /> | ||
*'''Botulinum neurotoxin type C''' induces apoptotic cell death in cerebellar neurons acting in birds, mammals and fish.<br /> | *'''Botulinum neurotoxin type C''' induces apoptotic cell death in cerebellar neurons acting in birds, mammals and fish.<br /> | ||
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*Type A Light Chain | *Type A Light Chain | ||
| - | **[[2g7k]], [[2g7p]], [[2g7q]], [[2imc]], [[3bwi]], [[ | + | **[[2g7k]], [[2g7p]], [[2g7q]], [[2imc]], [[3bwi]], [[3bon]], [[3qix]], [[2ise]], [[2isg]], [[2ish]], [[4ej5]] - CbCBN LC + Zn<br /> |
**[[3bok]] - CbCBN LC <br /> | **[[3bok]] - CbCBN LC <br /> | ||
**[[1e1h]], [[1xtf]], [[4kuf]], [[4el4]], [[4elc]] - CbCBN LC (mutant) + Zn<br /> | **[[1e1h]], [[1xtf]], [[4kuf]], [[4el4]], [[4elc]] - CbCBN LC (mutant) + Zn<br /> | ||
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**[[4ks6]], [[4ktx]] - CbCBN LC (mutant) + inhibitor peptide + Zn<br /> | **[[4ks6]], [[4ktx]] - CbCBN LC (mutant) + inhibitor peptide + Zn<br /> | ||
**[[3ds9]] – CbCBN LC (mutant) + inhibitor peptide + Zn + Ni<br /> | **[[3ds9]] – CbCBN LC (mutant) + inhibitor peptide + Zn + Ni<br /> | ||
| - | **[[3bon]] - CbCBN LC + Zn <br /> | ||
**[[3k3q]] - CbCBN LC + antibody + Zn<br /> | **[[3k3q]] - CbCBN LC + antibody + Zn<br /> | ||
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*Type A Light+Heavy Chain translocation domain | *Type A Light+Heavy Chain translocation domain | ||
| - | **[[2w2d]] - CbCBN LC+HC + Zn<br /> | + | **[[2w2d]], [[3bta]] - CbCBN LC+HC + Zn<br /> |
*'''Type B''' | *'''Type B''' | ||
Revision as of 17:00, 5 January 2016
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3D structures of botulinum neurotoxin
Updated on 05-January-2016
References
- ↑ Montecucco C, Molgo J. Botulinal neurotoxins: revival of an old killer. Curr Opin Pharmacol. 2005 Jun;5(3):274-9. PMID:15907915 doi:http://dx.doi.org/10.1016/j.coph.2004.12.006
- ↑ Lacy DB, Tepp W, Cohen AC, DasGupta BR, Stevens RC. Crystal structure of botulinum neurotoxin type A and implications for toxicity. Nat Struct Biol. 1998 Oct;5(10):898-902. PMID:9783750 doi:10.1038/2338
