1bg3
From Proteopedia
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|PDB= 1bg3 |SIZE=350|CAPTION= <scene name='initialview01'>1bg3</scene>, resolution 2.8Å | |PDB= 1bg3 |SIZE=350|CAPTION= <scene name='initialview01'>1bg3</scene>, resolution 2.8Å | ||
|SITE= | |SITE= | ||
| - | |LIGAND= <scene name='pdbligand= | + | |LIGAND= <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=G6P:ALPHA-D-GLUCOSE-6-PHOSPHATE'>G6P</scene>, <scene name='pdbligand=GLC:GLUCOSE'>GLC</scene> |
| - | |ACTIVITY= [http://en.wikipedia.org/wiki/Hexokinase Hexokinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.1 2.7.1.1] | + | |ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Hexokinase Hexokinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.1 2.7.1.1] </span> |
|GENE= | |GENE= | ||
| + | |DOMAIN= | ||
| + | |RELATEDENTRY= | ||
| + | |RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1bg3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1bg3 OCA], [http://www.ebi.ac.uk/pdbsum/1bg3 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1bg3 RCSB]</span> | ||
}} | }} | ||
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[[Category: Garavito, R M.]] | [[Category: Garavito, R M.]] | ||
[[Category: Mulichak, A M.]] | [[Category: Mulichak, A M.]] | ||
| - | [[Category: CA]] | ||
| - | [[Category: G6P]] | ||
| - | [[Category: GLC]] | ||
[[Category: hexokinase]] | [[Category: hexokinase]] | ||
[[Category: phosphotransferase]] | [[Category: phosphotransferase]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 19:00:11 2008'' |
Revision as of 16:00, 30 March 2008
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| , resolution 2.8Å | |||||||
|---|---|---|---|---|---|---|---|
| Ligands: | , , | ||||||
| Activity: | Hexokinase, with EC number 2.7.1.1 | ||||||
| Resources: | FirstGlance, OCA, PDBsum, RCSB | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
RAT BRAIN HEXOKINASE TYPE I COMPLEX WITH GLUCOSE AND INHIBITOR GLUCOSE-6-PHOSPHATE
Overview
We have determined the structures of the glucose-6-phosphate (G6P)-inhibitable 100,000 Mr Type I hexokinase from rat and the G6P-sensitive 50,000 Mr hexokinase from Schistosoma mansoni at a resolution of 2.8 and 2.6 A respectively. The structures define the glucose and G6P binding sites in these enzymes, suggest the mechanisms of intradomain G6P inhibition and activity loss in the Type I hexokinase N-terminal half, and reveal the structure of the membrane targeting motif that integrates the Type I hexokinase into the outer mitochondrial membrane.
About this Structure
1BG3 is a Single protein structure of sequence from Rattus norvegicus. Full crystallographic information is available from OCA.
Reference
The structure of mammalian hexokinase-1., Mulichak AM, Wilson JE, Padmanabhan K, Garavito RM, Nat Struct Biol. 1998 Jul;5(7):555-60. PMID:9665168
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