Phospholamban
From Proteopedia
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<StructureSection load='4y3u' size='340' side='right' caption='Dog phospholamban (green and pink) complex with calcium pump (grey) and K+ ion (purple) (PDB code [[4y3u]])' scene=''> | <StructureSection load='4y3u' size='340' side='right' caption='Dog phospholamban (green and pink) complex with calcium pump (grey) and K+ ion (purple) (PDB code [[4y3u]])' scene=''> | ||
| - | '''Phospholamban''' (PLB) is a 52-amino acid membrane protein that regulates the Ca+2 pump in cardiac and skeletal muscle cells. PLB functions as a homopentamer and is an inhibitor of Ca+2-ATPase in its unphosphorylated state. When PLB is phosphorylated by protein kinase A, it dissociates from Ca+2-ATPase and its inhibitory function is lost resulting in increase of ATPase activity. | ||
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== Function == | == Function == | ||
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| + | '''Phospholamban''' (PLB) is a 52-amino acid membrane protein that regulates the Ca+2 pump in cardiac and skeletal muscle cells. PLB functions as a homopentamer and is an inhibitor of Ca+2-ATPase in its unphosphorylated state. When PLB is phosphorylated by protein kinase A, it dissociates from Ca+2-ATPase and its inhibitory function is lost resulting in increase of ATPase activity. | ||
== Disease == | == Disease == | ||
Revision as of 12:00, 10 January 2016
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3D Structures of phospholamban
Updated on 10-January-2016
1plp – hPLB cytoplasmic domain – human - NMR
1zll, 2hyn – hPLB - NMR
1fjk, 1fjp – PLB – pig - NMR
1n7l, 2lpf – rPLB (mutant) – rabbit - NMR
2m3b – rPLB - NMR
2kb7, 2kyv – PLB – Escherichia coli - NMR
4kyt – dPLB (mutant) + calcium pump – dog
4y3u – dPLB + calcium pump
