Elastase
From Proteopedia
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| - | <StructureSection load='1eai' size='350' side='right' caption=' | + | <StructureSection load='1eai' size='350' side='right' caption='Pig elastase (grey, green) complex with chymotrypsin/elastase isoinhibitor (pink, yellow) (PDB code [[1eai]]).' scene=''> |
[[Elastase]] (ELA) is a chymotrypsin-like serine protease which breaks down proteins. The ELAs are numbered according to their genes. Panceatic ELA cleaves proteins at the carboxyl-terminal side of small neutral amino acids. It cleaves Ala-Ala and Ala-Gly bonds. <ref>PMID:12059069</ref> For additional details see [[Serine Proteases]]. | [[Elastase]] (ELA) is a chymotrypsin-like serine protease which breaks down proteins. The ELAs are numbered according to their genes. Panceatic ELA cleaves proteins at the carboxyl-terminal side of small neutral amino acids. It cleaves Ala-Ala and Ala-Gly bonds. <ref>PMID:12059069</ref> For additional details see [[Serine Proteases]]. | ||
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Pulmonary emphysema is caused by the destruction of elastic fibre by elastase. Mutations in ELA2 are linked to the genetic disorder cyclic hematopoeiesis. Neutrophil elastase is involved in the blistering in bullose pemphigoid. | Pulmonary emphysema is caused by the destruction of elastic fibre by elastase. Mutations in ELA2 are linked to the genetic disorder cyclic hematopoeiesis. Neutrophil elastase is involved in the blistering in bullose pemphigoid. | ||
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| + | == Structural highlights == | ||
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| + | ELA catalytic triad is Ser-His-Asp. | ||
</StructureSection> | </StructureSection> | ||
==3D structures of elastase== | ==3D structures of elastase== | ||
Revision as of 12:02, 11 January 2016
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3D structures of elastase
Updated on 11-January-2016
References
- ↑ Dominici R, Franzini C. Fecal elastase-1 as a test for pancreatic function: a review. Clin Chem Lab Med. 2002 Apr;40(4):325-32. PMID:12059069 doi:http://dx.doi.org/10.1515/CCLM.2002.051
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