This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.
Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.
4ud7
From Proteopedia
(Difference between revisions)
| Line 1: | Line 1: | ||
| - | ''' | + | ==Structure of the stapled peptide YS-02 bound to MDM2== |
| - | + | <StructureSection load='4ud7' size='340' side='right' caption='[[4ud7]], [[Resolution|resolution]] 1.60Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[4ud7]] is a 8 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4UD7 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4UD7 FirstGlance]. <br> | |
| - | + | </td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=2JN:2-METHYL-D-NORLEUCINE'>2JN</scene>, <scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene>, <scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene></td></tr> | |
| - | + | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4ue1|4ue1]]</td></tr> | |
| - | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ud7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ud7 OCA], [http://pdbe.org/4ud7 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4ud7 RCSB], [http://www.ebi.ac.uk/pdbsum/4ud7 PDBsum]</span></td></tr> | |
| - | [[Category: | + | </table> |
| - | [[Category: | + | == Disease == |
| - | [[Category: | + | [[http://www.uniprot.org/uniprot/MDM2_HUMAN MDM2_HUMAN]] Note=Seems to be amplified in certain tumors (including soft tissue sarcomas, osteosarcomas and gliomas). A higher frequency of splice variants lacking p53 binding domain sequences was found in late-stage and high-grade ovarian and bladder carcinomas. Four of the splice variants show loss of p53 binding. |
| - | [[Category: Lane, D | + | == Function == |
| + | [[http://www.uniprot.org/uniprot/MDM2_HUMAN MDM2_HUMAN]] E3 ubiquitin-protein ligase that mediates ubiquitination of p53/TP53, leading to its degradation by the proteasome. Inhibits p53/TP53- and p73/TP73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain. Also acts as an ubiquitin ligase E3 toward itself and ARRB1. Permits the nuclear export of p53/TP53. Promotes proteasome-dependent ubiquitin-independent degradation of retinoblastoma RB1 protein. Inhibits DAXX-mediated apoptosis by inducing its ubiquitination and degradation. Component of the TRIM28/KAP1-MDM2-p53/TP53 complex involved in stabilizing p53/TP53. Also component of the TRIM28/KAP1-ERBB4-MDM2 complex which links growth factor and DNA damage response pathways. Mediates ubiquitination and subsequent proteasome degradation of DYRK2 in nucleus. Ubiquitinates IGF1R and promotes it to proteasomal degradation.<ref>PMID:12821780</ref> <ref>PMID:15053880</ref> <ref>PMID:15195100</ref> <ref>PMID:16337594</ref> <ref>PMID:15632057</ref> <ref>PMID:17290220</ref> <ref>PMID:19098711</ref> <ref>PMID:19219073</ref> <ref>PMID:19965871</ref> <ref>PMID:20858735</ref> <ref>PMID:20173098</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Brown, C J]] | ||
| + | [[Category: Eapen, R S]] | ||
| + | [[Category: Gago, F J.F]] | ||
| + | [[Category: Jennings, C E]] | ||
| + | [[Category: Lane, D P]] | ||
| + | [[Category: Noble, M E.M]] | ||
[[Category: Reeks, J]] | [[Category: Reeks, J]] | ||
| - | [[Category: | + | [[Category: Tan, Y S]] |
[[Category: Thean, D]] | [[Category: Thean, D]] | ||
| - | + | [[Category: Tng, Q S]] | |
| - | + | ||
| - | + | ||
| - | [[Category: Tng, Q | + | |
| - | + | ||
[[Category: Verma, C]] | [[Category: Verma, C]] | ||
| + | [[Category: Ying, Y T]] | ||
| + | [[Category: Lyase]] | ||
| + | [[Category: Mdm2]] | ||
| + | [[Category: P53]] | ||
| + | [[Category: Stapled peptide]] | ||
Revision as of 20:20, 13 January 2016
Structure of the stapled peptide YS-02 bound to MDM2
| |||||||||||
Categories: Brown, C J | Eapen, R S | Gago, F J.F | Jennings, C E | Lane, D P | Noble, M E.M | Reeks, J | Tan, Y S | Thean, D | Tng, Q S | Verma, C | Ying, Y T | Lyase | Mdm2 | P53 | Stapled peptide
