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4xw2
From Proteopedia
(Difference between revisions)
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| - | ''' | + | ==Structural basis for simvastatin competitive antagonism of complement receptor 3== |
| - | + | <StructureSection load='4xw2' size='340' side='right' caption='[[4xw2]], [[Resolution|resolution]] 2.00Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[4xw2]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4XW2 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4XW2 FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=SIM:SIMVASTATIN+ACID'>SIM</scene></td></tr> | |
| - | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4xw2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4xw2 OCA], [http://pdbe.org/4xw2 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4xw2 RCSB], [http://www.ebi.ac.uk/pdbsum/4xw2 PDBsum]</span></td></tr> | |
| - | + | </table> | |
| - | [[ | + | == Disease == |
| - | [[ | + | [[http://www.uniprot.org/uniprot/ITAM_HUMAN ITAM_HUMAN]] Genetic variations in ITGAM has been associated with susceptibility to systemic lupus erythematosus type 6 (SLEB6) [MIM:[http://omim.org/entry/609939 609939]]. Systemic lupus erythematosus (SLE) is a chronic, inflammatory and often febrile multisystemic disorder of connective tissue. It affects principally the skin, joints, kidneys and serosal membranes. It is thought to represent a failure of the regulatory mechanisms of the autoimmune system. |
| - | [[ | + | == Function == |
| + | [[http://www.uniprot.org/uniprot/ITAM_HUMAN ITAM_HUMAN]] Integrin alpha-M/beta-2 is implicated in various adhesive interactions of monocytes, macrophages and granulocytes as well as in mediating the uptake of complement-coated particles. It is identical with CR-3, the receptor for the iC3b fragment of the third complement component. It probably recognizes the R-G-D peptide in C3b. Integrin alpha-M/beta-2 is also a receptor for fibrinogen, factor X and ICAM1. It recognizes P1 and P2 peptides of fibrinogen gamma chain. | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Andersen, G R]] | ||
[[Category: Bajic, G]] | [[Category: Bajic, G]] | ||
| - | [[Category: | + | [[Category: Jensen, M R]] |
| + | [[Category: Vorup-Jensen, T]] | ||
| + | [[Category: Complement receptor 3]] | ||
| + | [[Category: I domain]] | ||
| + | [[Category: Immune system]] | ||
| + | [[Category: Integrin]] | ||
| + | [[Category: Mac-1]] | ||
| + | [[Category: Protein-inhibitor complex]] | ||
| + | [[Category: Rossmann fold]] | ||
| + | [[Category: Statin]] | ||
| + | [[Category: Vwa]] | ||
Revision as of 20:23, 13 January 2016
Structural basis for simvastatin competitive antagonism of complement receptor 3
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