4yu0

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'''Unreleased structure'''
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==Crystal structure of a tetramer of GluA2 TR mutant ligand binding domains bound with glutamate at 1.26 Angstrom resolution==
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<StructureSection load='4yu0' size='340' side='right' caption='[[4yu0]], [[Resolution|resolution]] 1.26&Aring;' scene=''>
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The entry 4yu0 is ON HOLD until Paper Publication
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== Structural highlights ==
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<table><tr><td colspan='2'>[[4yu0]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4YU0 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4YU0 FirstGlance]. <br>
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Authors: Chebli, M., Salazar, H., Baranovic, J., Carbone, A.L., Ghisi, V., Faelber, K., Lau, A.Y., Daumke, O., Plested, A.J.R.
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GLU:GLUTAMIC+ACID'>GLU</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4yu0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4yu0 OCA], [http://pdbe.org/4yu0 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4yu0 RCSB], [http://www.ebi.ac.uk/pdbsum/4yu0 PDBsum]</span></td></tr>
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Description: Crystal structure of a tetramer of GluA2 TR mutant ligand binding domains bound with glutamate at 1.26 Angstrom resolution
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</table>
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[[Category: Unreleased Structures]]
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== Function ==
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[[Category: Ghisi, V]]
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[[http://www.uniprot.org/uniprot/GRIA2_RAT GRIA2_RAT]] Receptor for glutamate that functions as ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L-glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist. In the presence of CACNG4 or CACNG7 or CACNG8, shows resensitization which is characterized by a delayed accumulation of current flux upon continued application of glutamate.<ref>PMID:9351977</ref> <ref>PMID:19265014</ref> <ref>PMID:21172611</ref> <ref>PMID:12501192</ref> <ref>PMID:12015593</ref> <ref>PMID:12872125</ref> <ref>PMID:12730367</ref> <ref>PMID:16192394</ref> <ref>PMID:15591246</ref> <ref>PMID:17018279</ref> <ref>PMID:16483599</ref> <ref>PMID:19946266</ref> <ref>PMID:21317873</ref> <ref>PMID:21846932</ref>
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[[Category: Lau, A.Y]]
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== References ==
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<references/>
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__TOC__
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</StructureSection>
[[Category: Baranovic, J]]
[[Category: Baranovic, J]]
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[[Category: Carbone, A L]]
[[Category: Chebli, M]]
[[Category: Chebli, M]]
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[[Category: Daumke, O]]
[[Category: Faelber, K]]
[[Category: Faelber, K]]
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[[Category: Plested, A.J.R]]
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[[Category: Ghisi, V]]
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[[Category: Lau, A Y]]
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[[Category: Plested, A J.R]]
[[Category: Salazar, H]]
[[Category: Salazar, H]]
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[[Category: Daumke, O]]
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[[Category: Ligand-gated ion channel]]
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[[Category: Carbone, A.L]]
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[[Category: Tetramer]]
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[[Category: Transport protein]]

Revision as of 20:24, 13 January 2016

Crystal structure of a tetramer of GluA2 TR mutant ligand binding domains bound with glutamate at 1.26 Angstrom resolution

4yu0, resolution 1.26Å

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