5els
From Proteopedia
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| - | ''' | + | ==Structure of the KH domain of T-STAR in complex with AAAUAA RNA== |
| - | + | <StructureSection load='5els' size='340' side='right' caption='[[5els]], [[Resolution|resolution]] 2.87Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[5els]] is a 8 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5ELS OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5ELS FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> | |
| - | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5els FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5els OCA], [http://pdbe.org/5els PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5els RCSB], [http://www.ebi.ac.uk/pdbsum/5els PDBsum]</span></td></tr> | |
| - | + | </table> | |
| - | [ | + | == Function == |
| + | [[http://www.uniprot.org/uniprot/KHDR3_HUMAN KHDR3_HUMAN]] RNA-binding protein that plays a role in the regulation of alternative splicing and influences mRNA splice site selection and exon inclusion. May play a role as a negative regulator of cell growth. Inhibits cell proliferation. Involved in splice site selection of vascular endothelial growth factor. Induces an increased concentration-dependent incorporation of exon in CD44 pre-mRNA by direct binding to purine-rich exonic enhancer. RNA-binding abilities are down-regulated by tyrosine kinase PTK6. Involved in post-transcriptional regulation of HIV-1 gene expression. Binds preferentially to the 5'-[AU]UAAA-3' motif in vitro.<ref>PMID:10564820</ref> <ref>PMID:11741900</ref> <ref>PMID:15901763</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
[[Category: Dominguez, C]] | [[Category: Dominguez, C]] | ||
[[Category: Feracci, M]] | [[Category: Feracci, M]] | ||
| + | [[Category: Protein - rna complexes star protein alternative splicing kh domain]] | ||
| + | [[Category: Rna binding protein]] | ||
Revision as of 20:33, 13 January 2016
Structure of the KH domain of T-STAR in complex with AAAUAA RNA
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