5fg4

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m (Protected "5fg4" [edit=sysop:move=sysop])
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'''Unreleased structure'''
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==Crystal structure of the bromodomain of human BRPF1 in complex with OF-1 chemical probe==
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<StructureSection load='5fg4' size='340' side='right' caption='[[5fg4]], [[Resolution|resolution]] 1.65&Aring;' scene=''>
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The entry 5fg4 is ON HOLD
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== Structural highlights ==
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<table><tr><td colspan='2'>[[5fg4]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5FG4 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5FG4 FirstGlance]. <br>
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Authors: Tallant, C., Owen, D.R., Gerstenberger, B.S., Savitsky, P., Chaikuad, A., Fedorov, O., Nunez-Alonso, G., Filippakopoulos, P., von Delft, F., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Muller, S., Knapp, S.
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=5XE:4-BROMANYL-~{N}-(6-METHOXY-1,3-DIMETHYL-2-OXIDANYLIDENE-BENZIMIDAZOL-5-YL)-2-METHYL-BENZENESULFONAMIDE'>5XE</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5fg4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5fg4 OCA], [http://pdbe.org/5fg4 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5fg4 RCSB], [http://www.ebi.ac.uk/pdbsum/5fg4 PDBsum]</span></td></tr>
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Description: Crystal structure of the bromodomain of human BRPF1 in complex with OF-1 chemical probe
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</table>
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[[Category: Unreleased Structures]]
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== Function ==
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[[Category: Gerstenberger, B.S]]
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[[http://www.uniprot.org/uniprot/BRPF1_HUMAN BRPF1_HUMAN]] Component of the MOZ/MORF complex which has a histone H3 acetyltransferase activity. Positively regulates the transcription of RUNX1 and RUNX2.<ref>PMID:16387653</ref> <ref>PMID:18794358</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Arrowsmith, C H]]
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[[Category: Bountra, C]]
[[Category: Chaikuad, A]]
[[Category: Chaikuad, A]]
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[[Category: Owen, D.R]]
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[[Category: Delft, F von]]
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[[Category: Nunez-Alonso, G]]
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[[Category: Edwards, A M]]
[[Category: Fedorov, O]]
[[Category: Fedorov, O]]
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[[Category: Muller, S]]
 
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[[Category: Knapp, S]]
 
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[[Category: Bountra, C]]
 
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[[Category: Arrowsmith, C.H]]
 
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[[Category: Von Delft, F]]
 
[[Category: Filippakopoulos, P]]
[[Category: Filippakopoulos, P]]
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[[Category: Edwards, A.M]]
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[[Category: Gerstenberger, B S]]
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[[Category: Tallant, C]]
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[[Category: Knapp, S]]
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[[Category: Muller, S]]
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[[Category: Nunez-Alonso, G]]
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[[Category: Owen, D R]]
[[Category: Savitsky, P]]
[[Category: Savitsky, P]]
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[[Category: Tallant, C]]
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[[Category: Moz-morf complex]]
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[[Category: Peregrin]]
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[[Category: Transcription]]

Revision as of 20:37, 13 January 2016

Crystal structure of the bromodomain of human BRPF1 in complex with OF-1 chemical probe

5fg4, resolution 1.65Å

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