5fpv

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
-
'''Unreleased structure'''
+
==Crystal structure of human JMJD2A in complex with compound KDOAM20A==
-
 
+
<StructureSection load='5fpv' size='340' side='right' caption='[[5fpv]], [[Resolution|resolution]] 2.44&Aring;' scene=''>
-
The entry 5fpv is ON HOLD
+
== Structural highlights ==
-
 
+
<table><tr><td colspan='2'>[[5fpv]] is a 8 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5FPV OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5FPV FirstGlance]. <br>
-
Authors: Srikannathasan, V., Gileadi, C., von Delft, F., Arrowsmith, C.H., Bountra, C., Edwards, A., Oppermann, U.
+
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MMK:2-{[(2-{[(E)-2-(DIMETHYLAMINO)ETHENYL](ETHYL)AMINO}-2-OXOETHYL)AMINO]METHYL}PYRIDINE-4-CARBOXYLIC+ACID'>MMK</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>, <scene name='pdbligand=NI:NICKEL+(II)+ION'>NI</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-
 
+
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5fpl|5fpl]], [[5fpu|5fpu]]</td></tr>
-
Description: Crystal structure of human JMJD2A in complex with compound KDOAM20A
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5fpv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5fpv OCA], [http://pdbe.org/5fpv PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5fpv RCSB], [http://www.ebi.ac.uk/pdbsum/5fpv PDBsum]</span></td></tr>
-
[[Category: Unreleased Structures]]
+
</table>
 +
== Function ==
 +
[[http://www.uniprot.org/uniprot/KDM4A_HUMAN KDM4A_HUMAN]] Histone demethylase that specifically demethylates 'Lys-9' and 'Lys-36' residues of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-4', H3 'Lys-27' nor H4 'Lys-20'. Demethylates trimethylated H3 'Lys-9' and H3 'Lys-36' residue, while it has no activity on mono- and dimethylated residues. Demethylation of Lys residue generates formaldehyde and succinate. Participates in transcriptional repression of ASCL2 and E2F-responsive promoters via the recruitment of histone deacetylases and NCOR1, respectively.<ref>PMID:16024779</ref> <ref>PMID:16603238</ref> <ref>PMID:21694756</ref> Isoform 2: Crucial for muscle differentiation, promotes transcriptional activation of the Myog gene by directing the removal of repressive chromatin marks at its promoter. Lacks the N-terminal demethylase domain.<ref>PMID:16024779</ref> <ref>PMID:16603238</ref> <ref>PMID:21694756</ref>
 +
== References ==
 +
<references/>
 +
__TOC__
 +
</StructureSection>
 +
[[Category: Arrowsmith, C H]]
[[Category: Bountra, C]]
[[Category: Bountra, C]]
-
[[Category: Arrowsmith, C.H]]
+
[[Category: Delft, F von]]
 +
[[Category: Edwards, A]]
[[Category: Gileadi, C]]
[[Category: Gileadi, C]]
[[Category: Oppermann, U]]
[[Category: Oppermann, U]]
-
[[Category: Von Delft, F]]
 
-
[[Category: Edwards, A]]
 
[[Category: Srikannathasan, V]]
[[Category: Srikannathasan, V]]
 +
[[Category: Jmjd2a]]
 +
[[Category: Kdm4a]]
 +
[[Category: Oxidoreductase]]

Revision as of 20:37, 13 January 2016

Crystal structure of human JMJD2A in complex with compound KDOAM20A

5fpv, resolution 2.44Å

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/5fpv"
Personal tools