Centromere protein

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<StructureSection load='3vh5' size='340' side='right' caption='Structure of chicken CENP-X (yellow), CENP-S (cyan), CENP-W (purple) and CENP-T C-terminal (dark green) (PDB code [[3vh5]]).' scene='59/596426/Cv/1'>
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<StructureSection load='3vh5' size='350' side='right' caption='Structure of chicken CENP-X (yellow), CENP-S (cyan), CENP-W (magenta) and CENP-T C-terminal (green) (PDB code [[3vh5]]).' scene='59/596426/Cv/1'>
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__TOC__
== Function ==
== Function ==
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CENP-B is a potential marker for lung cancer.
CENP-B is a potential marker for lung cancer.
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== Structural highlights ==
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<scene name='59/596426/Cv/2'>chicken CENP-T histone fold/CENP-W/CENP-S/CENP-X heterotetrameric complex</scene> (PDB code [[3vh5]]).<ref>PMID:22304917</ref>
</StructureSection>
</StructureSection>

Revision as of 10:01, 18 January 2016

Structure of chicken CENP-X (yellow), CENP-S (cyan), CENP-W (magenta) and CENP-T C-terminal (green) (PDB code 3vh5).

Drag the structure with the mouse to rotate

3D structures of centromere protein

Updated on 18-January-2016

References

  1. ↑ Tanaka Y, Nureki O, Kurumizaka H, Fukai S, Kawaguchi S, Ikuta M, Iwahara J, Okazaki T, Yokoyama S. Crystal structure of the CENP-B protein-DNA complex: the DNA-binding domains of CENP-B induce kinks in the CENP-B box DNA. EMBO J. 2001 Dec 3;20(23):6612-8. PMID:11726497 doi:10.1093/emboj/20.23.6612
  2. ↑ Sekulic N, Bassett EA, Rogers DJ, Black BE. The structure of (CENP-A-H4)(2) reveals physical features that mark centromeres. Nature. 2010 Aug 25. PMID:20739937 doi:10.1038/nature09323
  3. ↑ Garcia-Saez I, Blot D, Kahn R, Kozielski F. Crystallization and preliminary crystallographic analysis of the motor domain of human kinetochore-associated protein CENP-E using an automated crystallization procedure. Acta Crystallogr D Biol Crystallogr. 2004 Jun;60(Pt 6):1158-60. Epub 2004, May 21. PMID:15159587 doi:http://dx.doi.org/10.1107/S0907444904009564
  4. ↑ Basilico F, Maffini S, Weir JR, Prumbaum D, Rojas AM, Zimniak T, De Antoni A, Jeganathan S, Voss B, van Gerwen S, Krenn V, Massimiliano L, Valencia A, Vetter IR, Herzog F, Raunser S, Pasqualato S, Musacchio A. The pseudo GTPase CENP-M drives human kinetochore assembly. Elife (Cambridge). 2014 Jul 8;3:e02978. doi: 10.7554/eLife.02978. PMID:25006165
  5. ↑ Jeyaprakash AA, Klein UR, Lindner D, Ebert J, Nigg EA, Conti E. Structure of a Survivin-Borealin-INCENP core complex reveals how chromosomal passengers travel together. Cell. 2007 Oct 19;131(2):271-85. PMID:17956729 doi:http://dx.doi.org/10.1016/j.cell.2007.07.045
  6. ↑ Nishino T, Takeuchi K, Gascoigne KE, Suzuki A, Hori T, Oyama T, Morikawa K, Cheeseman IM, Fukagawa T. CENP-T-W-S-X Forms a Unique Centromeric Chromatin Structure with a Histone-like Fold. Cell. 2012 Feb 3;148(3):487-501. PMID:22304917 doi:10.1016/j.cell.2011.11.061

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