Epidermal growth factor
From Proteopedia
(Difference between revisions)
| Line 1: | Line 1: | ||
| - | + | <StructureSection load='1j19' size='350' side='right' scene='' caption='Dimer of the monomeric human epidermal growth factor (PDB code [[1j19]]) '> | |
| - | + | == Function == | |
| - | '''Epidermal growth factor''' (EGF) plays a role in cell growth. It binds to its receptor ([[Epidermal Growth Factor Receptor|EGFR]]). EGF is regulated by iodine. EGF is part of a family of proteins with similar structure and activity. All EGF family proteins contain a conserved amino acid sequence which includes 3 disulfide bonds. Some details on EGF exon in [[EGF1]]. | + | |
| + | '''Epidermal growth factor''' (EGF) plays a role in cell growth. It binds to its receptor ([[Epidermal Growth Factor Receptor|EGFR]]). EGF is regulated by iodine. EGF is part of a family of proteins with similar structure and activity. All EGF family proteins contain a conserved amino acid sequence which includes 3 disulfide bonds<ref>PMID:2186024</ref>. Some details on EGF exon in [[EGF1]]. | ||
| + | |||
| + | == Relevance == | ||
| + | |||
| + | EGFR-dependent cancers are deprived of stimulus by EGF by raising antibodies against it. | ||
| + | </StructureSection> | ||
==3D structures of epidermal growth factor== | ==3D structures of epidermal growth factor== | ||
| Line 26: | Line 32: | ||
**[[2j5h]] – mCR-EGF residues 96-134 - NMR | **[[2j5h]] – mCR-EGF residues 96-134 - NMR | ||
}} | }} | ||
| + | == References == | ||
| + | <references/> | ||
| + | |||
[[Category:Topic Page]] | [[Category:Topic Page]] | ||
Revision as of 19:46, 19 January 2016
| |||||||||||
3D structures of epidermal growth factor
Updated on 19-January-2016
