Ets1

(Difference between revisions)

Revision as of 15:44, 20 January 2016

Structure of mouse Ets1 ETS domain (green) complex with paired box protein Pax5 (grey) and MB-1 promoter DNA (PDB code 1mdm).

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Updated on 20-January-2016

↑ Dwyer J, Li H, Xu D, Liu JP. Transcriptional regulation of telomerase activity: roles of the the Ets transcription factor family. Ann N Y Acad Sci. 2007 Oct;1114:36-47. PMID:17986575 doi:http://dx.doi.org/10.1196/annals.1396.022

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 == Function ==
-'''Ets1 (E26 Transformation-Specific)''' is a proto-oncogene translation factor.  Ets1 contributes to the regulation of cellular differentiation.  Ets1 contains an ETS domain which is a helix-turn-helix DNA-binding domain which recognizes the sequence GGAA/T.  The ETS domain is flanked by autoinhibitory domains.  At the N-terminal, Ets1 contains a pointed domain (PNT) and a MAP kinase phosphorylation domain.  PNT domain is related to SAM domains and contains 4 α-helices.
+'''Ets1 (E26 Transformation-Specific)''' is a proto-oncogene translation factor.  Ets1 contributes to the regulation of cellular differentiation<ref>PMID:17986575</ref>  .
 == Disease ==
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 == Structural highlights ==
+Ets1 contains an ETS domain which is a helix-turn-helix DNA-binding domain which recognizes the sequence GGAA/T.  The ETS domain is flanked by autoinhibitory domains.  At the N-terminal, Ets1 contains a pointed domain (PNT) and a MAP kinase phosphorylation domain.  PNT domain is related to SAM domains and contains 4 α-helices.
 </StructureSection>