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Ets1
From Proteopedia
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== Function == | == Function == | ||
| - | '''Ets1 (E26 Transformation-Specific)''' is a proto-oncogene translation factor. Ets1 contributes to the regulation of cellular differentiation | + | '''Ets1 (E26 Transformation-Specific)''' is a proto-oncogene translation factor. Ets1 contributes to the regulation of cellular differentiation<ref>PMID:17986575</ref> . |
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== Disease == | == Disease == | ||
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== Structural highlights == | == Structural highlights == | ||
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| + | Ets1 contains an ETS domain which is a helix-turn-helix DNA-binding domain which recognizes the sequence GGAA/T. The ETS domain is flanked by autoinhibitory domains. At the N-terminal, Ets1 contains a pointed domain (PNT) and a MAP kinase phosphorylation domain. PNT domain is related to SAM domains and contains 4 α-helices. | ||
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</StructureSection> | </StructureSection> | ||
Revision as of 15:44, 20 January 2016
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3D Structures of Ets1
Updated on 20-January-2016
References
- ↑ Dwyer J, Li H, Xu D, Liu JP. Transcriptional regulation of telomerase activity: roles of the the Ets transcription factor family. Ann N Y Acad Sci. 2007 Oct;1114:36-47. PMID:17986575 doi:http://dx.doi.org/10.1196/annals.1396.022
