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Ets1

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== Structural highlights ==
== Structural highlights ==
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Ets1 contains an ETS domain which is a helix-turn-helix DNA-binding domain which recognizes the sequence GGAA/T. The ETS domain is flanked by autoinhibitory domains. At the N-terminal, Ets1 contains a pointed domain (PNT) and a MAP kinase phosphorylation domain. PNT domain is related to SAM domains and contains 4 α-helices.
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Ets1 contains an ETS domain (residues 332-415) which is a helix-turn-helix DNA-binding domain which recognizes the sequence GGAA/T. The ETS domain is flanked by autoinhibitory domains. At the N-terminal, Ets1 contains a pointed domain (PNT) (residues 54-135) and a MAP kinase phosphorylation domain. PNT domain is related to SAM domains and contains 4 α-helices.
</StructureSection>
</StructureSection>
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*Ets1 binary complexes
*Ets1 binary complexes
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**[[2nny]] – hETS1 + DNA <br />
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**[[2nny]] – hETS1 residues 280-441 + DNA <br />
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**[[3mfk]] – hETS1 + stromelysin promoter DNA <br />
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**[[3mfk]] – hETS1 residues 280-441 + stromelysin promoter DNA <br />
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**[[3ri4]] – hETS1 + TCR α promoter DNA <br />
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**[[3ri4]] – hETS1 residues 280-441 + TCR α promoter DNA <br />
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**[[2stt]], [[2stw]] – hETS1 + DNA - NMR<br />
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**[[2stt]], [[2stw]] – hETS1 ETS domain + DNA - NMR<br />
**[[1k79]], [[1k7a]] – mETS1 ETS domain + DNA containing GGAA - mouse<br />
**[[1k79]], [[1k7a]] – mETS1 ETS domain + DNA containing GGAA - mouse<br />
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**[[1mdm]] – mETS1 ETS domain + paired box protein Pax5 + MB-1 promoter DNA <br />
**[[1mdm]] – mETS1 ETS domain + paired box protein Pax5 + MB-1 promoter DNA <br />
**[[1k78]] – hETS1 ETS domain + paired box protein Pax5 + MB-1 promoter DNA - NMR<br />
**[[1k78]] – hETS1 ETS domain + paired box protein Pax5 + MB-1 promoter DNA - NMR<br />
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**[[4l0y]], [[4l0z]], [[4l18]] – hETS1 + TCR α promoter DNA + RunT-related transcription factor<br />
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**[[4l0y]], [[4l0z]], [[4l18]] – hETS1 residues 296-441 + TCR α promoter DNA + RunT-related transcription factor<br />
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**[[4lg0]] – hETS1 + cadherin promoter DNA + forkhead box protein<br />
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**[[4lg0]] – hETS1 residues 280-441 + cadherin promoter DNA + forkhead box protein<br />
}}
}}

Revision as of 16:42, 20 January 2016

Structure of mouse Ets1 ETS domain (green) complex with paired box protein Pax5 (grey) and MB-1 promoter DNA (PDB code 1mdm).

Drag the structure with the mouse to rotate

3D Structures of Ets1

Updated on 20-January-2016

References

  1. ↑ Dwyer J, Li H, Xu D, Liu JP. Transcriptional regulation of telomerase activity: roles of the the Ets transcription factor family. Ann N Y Acad Sci. 2007 Oct;1114:36-47. PMID:17986575 doi:http://dx.doi.org/10.1196/annals.1396.022

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky, Jaime Prilusky

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