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Eukaryotic initiation factor
From Proteopedia
(Difference between revisions)
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| + | == Function == | ||
| - | '''Eukaryotic initiation factors''' (EIF) are involved in the initiation of protein translation. They form a complex with the small subunit of the ribosome and Met-tRNA which scans the mRNA and recognizes the initiation codon AUG. EIF domains include the N terminal domain (NTD), C terminal domain (CTD), RNA recognition domain, middle domain, PAZ domain of EIF2C and a protein-protein interaction domain (PCI) of EIF3. | + | '''Eukaryotic initiation factors''' (EIF) are involved in the initiation of protein translation. They form a complex with the small subunit of the ribosome and Met-tRNA which scans the mRNA and recognizes the initiation codon AUG<ref>PMID:16449648</ref>. For details on EIF4 see [[C-terminal portion of human eIF4GI]]. |
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| + | == Disease == | ||
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| + | Overexpression of individual subunits of eIF3 may cause malignant transformation <ref>PMID:25450521</ref>. | ||
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| + | == Structural insights == | ||
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| + | EIF domains include the N terminal domain (NTD), C terminal domain (CTD), RNA recognition domain, middle domain, PAZ domain of EIF2C and a protein-protein interaction domain (PCI) of EIF3. | ||
| + | </StructureSection> | ||
==3D structures of eukaryotic initiation factor== | ==3D structures of eukaryotic initiation factor== | ||
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**[[3j2i]] – yEIF6 + proliferation-associated protein 2G4 – cryo EM<br /> | **[[3j2i]] – yEIF6 + proliferation-associated protein 2G4 – cryo EM<br /> | ||
}} | }} | ||
| + | == References == | ||
| + | <references/> | ||
Revision as of 16:54, 20 January 2016
Contents |
Function
Eukaryotic initiation factors (EIF) are involved in the initiation of protein translation. They form a complex with the small subunit of the ribosome and Met-tRNA which scans the mRNA and recognizes the initiation codon AUG[1]. For details on EIF4 see C-terminal portion of human eIF4GI.
Disease
Overexpression of individual subunits of eIF3 may cause malignant transformation [2].
Structural insights
EIF domains include the N terminal domain (NTD), C terminal domain (CTD), RNA recognition domain, middle domain, PAZ domain of EIF2C and a protein-protein interaction domain (PCI) of EIF3. </StructureSection>
3D structures of eukaryotic initiation factor
Updated on 20-January-2016
References
- ↑ Jivotovskaya AV, Valasek L, Hinnebusch AG, Nielsen KH. Eukaryotic translation initiation factor 3 (eIF3) and eIF2 can promote mRNA binding to 40S subunits independently of eIF4G in yeast. Mol Cell Biol. 2006 Feb;26(4):1355-72. PMID:16449648 doi:http://dx.doi.org/10.1128/MCB.26.4.1355-1372.2006
- ↑ Hershey JW. The role of eIF3 and its individual subunits in cancer. Biochim Biophys Acta. 2015 Jul;1849(7):792-800. doi:, 10.1016/j.bbagrm.2014.10.005. Epub 2014 Nov 1. PMID:25450521 doi:http://dx.doi.org/10.1016/j.bbagrm.2014.10.005
