3j07
From Proteopedia
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| - | ''' | + | ==Model of a 24mer alphaB-crystallin multimer== |
| + | <StructureSection load='3j07' size='340' side='right' caption='[[3j07]], [[NMR_Ensembles_of_Models | 1 NMR models]]' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[3j07]] is a 24 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3J07 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3J07 FirstGlance]. <br> | ||
| + | </td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2klr|2klr]]</td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3j07 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3j07 OCA], [http://pdbe.org/3j07 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3j07 RCSB], [http://www.ebi.ac.uk/pdbsum/3j07 PDBsum]</span></td></tr> | ||
| + | </table> | ||
| + | == Disease == | ||
| + | [[http://www.uniprot.org/uniprot/CRYAB_HUMAN CRYAB_HUMAN]] Posterior polar cataract;Alpha-crystallinopathy;Zonular cataract;Familial isolated dilated cardiomyopathy;Fatal infantile hypertonic myofibrillar myopathy. The disease is caused by mutations affecting the gene represented in this entry. The disease is caused by mutations affecting the gene represented in this entry. The disease is caused by mutations affecting the gene represented in this entry. The disease is caused by mutations affecting the gene represented in this entry. | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/CRYAB_HUMAN CRYAB_HUMAN]] May contribute to the transparency and refractive index of the lens. Has chaperone-like activity, preventing aggregation of various proteins under a wide range of stress conditions. | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | Alpha-crystallins are molecular chaperones that protect vertebrate eye lens proteins from detrimental protein aggregation. alphaB-Crystallin, 1 of the 2 alpha-crystallin isoforms, is also associated with myopathies and neuropathological diseases. Despite the importance of alpha-crystallins in protein homeostasis, only little is known about their quaternary structures because of their seemingly polydisperse nature. Here, we analyzed the structures of recombinant alpha-crystallins using biophysical methods. In contrast to previous reports, we show that alphaB-crystallin assembles into defined oligomers consisting of 24 subunits. The 3-dimensional (3D) reconstruction of alphaB-crystallin by electron microscopy reveals a sphere-like structure with large openings to the interior of the protein. alphaA-Crystallin forms, in addition to complexes of 24 subunits, also smaller oligomers and large clusters consisting of individual oligomers. This propensity might explain the previously reported polydisperse nature of alpha-crystallin. | ||
| - | The | + | The eye lens chaperone alpha-crystallin forms defined globular assemblies.,Peschek J, Braun N, Franzmann TM, Georgalis Y, Haslbeck M, Weinkauf S, Buchner J Proc Natl Acad Sci U S A. 2009 Aug 11;106(32):13272-7. doi:, 10.1073/pnas.0902651106. Epub 2009 Jul 27. PMID:19651604<ref>PMID:19651604</ref> |
| - | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |
| - | + | </div> | |
| - | + | <div class="pdbe-citations 3j07" style="background-color:#fffaf0;"></div> | |
| - | + | == References == | |
| - | + | <references/> | |
| - | + | __TOC__ | |
| + | </StructureSection> | ||
[[Category: Bardiaux, B]] | [[Category: Bardiaux, B]] | ||
| + | [[Category: Dove, K K]] | ||
[[Category: Gonen, T]] | [[Category: Gonen, T]] | ||
[[Category: Jehle, S]] | [[Category: Jehle, S]] | ||
| - | [[Category: Klevit, R | + | [[Category: Klevit, R E]] |
| + | [[Category: Oschkinat, H]] | ||
| + | [[Category: Rajagopal, P]] | ||
[[Category: Vollmar, B]] | [[Category: Vollmar, B]] | ||
| - | [[Category: | + | [[Category: Chaperone]] |
| + | [[Category: Shsp]] | ||
Revision as of 17:03, 20 January 2016
Model of a 24mer alphaB-crystallin multimer
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Categories: Bardiaux, B | Dove, K K | Gonen, T | Jehle, S | Klevit, R E | Oschkinat, H | Rajagopal, P | Vollmar, B | Chaperone | Shsp
