4d76

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'''Unreleased structure'''
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==Human FXIa in complex with small molecule inhibitors.==
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<StructureSection load='4d76' size='340' side='right' caption='[[4d76]], [[Resolution|resolution]] 1.77&Aring;' scene=''>
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The entry 4d76 is ON HOLD until Paper Publication
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== Structural highlights ==
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<table><tr><td colspan='2'>[[4d76]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4D76 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4D76 FirstGlance]. <br>
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Authors: Sandmark, J., Oster, L., Jacso, T., Ullah, V., Redzick, A., Borjesson, U., Olsson, T., Norberg, M., Akerud, T.
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=J1J:N-[(2S)-1-({5-[(DIAMINOMETHYLIDENE)AMINO]PENTYL}AMINO)-1-OXO-3-PHENYLPROPAN-2-YL]-4-HYDROXY-2-OXO-1,2-DIHYDROQUINOLINE-6-CARBOXAMIDE'>J1J</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4d7f|4d7f]], [[4d7g|4d7g]]</td></tr>
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Description: Human FXIa in complex with small molecule inhibitors.
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Coagulation_factor_XIa Coagulation factor XIa], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.27 3.4.21.27] </span></td></tr>
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[[Category: Unreleased Structures]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4d76 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4d76 OCA], [http://pdbe.org/4d76 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4d76 RCSB], [http://www.ebi.ac.uk/pdbsum/4d76 PDBsum]</span></td></tr>
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[[Category: Norberg, M]]
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</table>
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[[Category: Redzick, A]]
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== Disease ==
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[[Category: Oster, L]]
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[[http://www.uniprot.org/uniprot/FA11_HUMAN FA11_HUMAN]] Defects in F11 are the cause of factor XI deficiency (FA11D) [MIM:[http://omim.org/entry/612416 612416]]; also known as plasma thromboplastin antecedent deficiency or Rosenthal syndrome. It is a hemorrhagic disease characterized by reduced levels and activity of factor XI resulting in moderate bleeding symptoms, usually occurring after trauma or surgery. Patients usually do not present spontaneous bleeding but women can present with menorrhagia. Hemorrhages are usually moderate.<ref>PMID:2813350</ref> <ref>PMID:1547342</ref> <ref>PMID:7888672</ref> <ref>PMID:7669672</ref> <ref>PMID:9401068</ref> <ref>PMID:9787168</ref> <ref>PMID:10027710</ref> <ref>PMID:10606881</ref> <ref>PMID:11895778</ref> <ref>PMID:15026311</ref> <ref>PMID:15180874</ref> <ref>PMID:15953011</ref> <ref>PMID:16607084</ref> <ref>PMID:18005151</ref> <ref>PMID:21668437</ref> <ref>PMID:21457405</ref> <ref>PMID:22016685</ref> <ref>PMID:22322133</ref> <ref>PMID:21999818</ref> <ref>PMID:22159456</ref>
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[[Category: Ullah, V]]
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== Function ==
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[[Category: Olsson, T]]
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[[http://www.uniprot.org/uniprot/FA11_HUMAN FA11_HUMAN]] Factor XI triggers the middle phase of the intrinsic pathway of blood coagulation by activating factor IX.
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Coagulation factor XIa]]
[[Category: Akerud, T]]
[[Category: Akerud, T]]
[[Category: Borjesson, U]]
[[Category: Borjesson, U]]
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[[Category: Sandmark, J]]
 
[[Category: Jacso, T]]
[[Category: Jacso, T]]
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[[Category: Norberg, M]]
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[[Category: Olsson, T]]
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[[Category: Oster, L]]
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[[Category: Redzick, A]]
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[[Category: Sandmark, J]]
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[[Category: Ullah, V]]
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[[Category: Hydrolase]]
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[[Category: Serine protease]]

Revision as of 17:09, 20 January 2016

Human FXIa in complex with small molecule inhibitors.

4d76, resolution 1.77Å

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