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4uf4

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'''Unreleased structure'''
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==Crystal structure of the human CARBOXYPEPTIDASE A1 in complex with a thiirane mechanism-based inhibitor==
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<StructureSection load='4uf4' size='340' side='right' caption='[[4uf4]], [[Resolution|resolution]] 1.77&Aring;' scene=''>
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The entry 4uf4 is ON HOLD until Paper Publication
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== Structural highlights ==
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<table><tr><td colspan='2'>[[4uf4]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4UF4 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4UF4 FirstGlance]. <br>
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Authors: Gallego, P., Granados, C., Pallares, I., Covaleda, G., Aviles, F.X., Vendrell, J., Reverter, D.
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=O2V:(2S)-4-METHYL-2-[(1R)-1-SULFANYLETHYL]PENTANOIC+ACID'>O2V</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4uee|4uee]], [[4uef|4uef]], [[4uez|4uez]], [[5aek|5aek]]</td></tr>
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Description: Crystal structure of the human CARBOXYPEPTIDASE A1 in complex with a thiirane mechanism-based inhibitor
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Carboxypeptidase_A Carboxypeptidase A], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.17.1 3.4.17.1] </span></td></tr>
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[[Category: Unreleased Structures]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4uf4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4uf4 OCA], [http://pdbe.org/4uf4 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4uf4 RCSB], [http://www.ebi.ac.uk/pdbsum/4uf4 PDBsum]</span></td></tr>
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[[Category: Gallego, P]]
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</table>
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[[Category: Aviles, F.X]]
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== Function ==
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[[Category: Reverter, D]]
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[[http://www.uniprot.org/uniprot/CBPA1_HUMAN CBPA1_HUMAN]] Carboxypeptidase that catalyzes the release of a C-terminal amino acid, but has little or no action with -Asp, -Glu, -Arg, -Lys or -Pro.<ref>PMID:8806703</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Carboxypeptidase A]]
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[[Category: Aviles, F X]]
[[Category: Covaleda, G]]
[[Category: Covaleda, G]]
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[[Category: Vendrell, J]]
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[[Category: Gallego, P]]
[[Category: Granados, C]]
[[Category: Granados, C]]
[[Category: Pallares, I]]
[[Category: Pallares, I]]
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[[Category: Reverter, D]]
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[[Category: Vendrell, J]]
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[[Category: Hydrolase]]

Revision as of 17:10, 20 January 2016

Crystal structure of the human CARBOXYPEPTIDASE A1 in complex with a thiirane mechanism-based inhibitor

4uf4, resolution 1.77Å

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