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4z43

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'''Unreleased structure'''
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==Crystal structure of Tryptophan 7-halogenase (PrnA) Mutant E450K==
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<StructureSection load='4z43' size='340' side='right' caption='[[4z43]], [[Resolution|resolution]] 2.29&Aring;' scene=''>
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The entry 4z43 is ON HOLD
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== Structural highlights ==
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<table><tr><td colspan='2'>[[4z43]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4Z43 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4Z43 FirstGlance]. <br>
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Authors: Levy, C.W.
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Tryptophan_7-halogenase Tryptophan 7-halogenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.14.19.9 1.14.19.9] </span></td></tr>
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Description: Crystal structure of Tryptophan 7-halogenase (PrnA) Mutant E450K
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4z43 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4z43 OCA], [http://pdbe.org/4z43 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4z43 RCSB], [http://www.ebi.ac.uk/pdbsum/4z43 PDBsum]</span></td></tr>
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[[Category: Unreleased Structures]]
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</table>
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[[Category: Levy, C.W]]
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== Function ==
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[[http://www.uniprot.org/uniprot/PRNA_PSEFL PRNA_PSEFL]] Involved in the biosynthesis of the antifungal antibiotic pyrrolnitrin. Catalyze the chlorination of tryptophan (Trp) at C7 position to yield 7-chloro-L-tryptophan (7-CLT). The reaction between FADH2, Cl-, and O2 generates the powerful oxidant HOCl, which is presumed to carry out the chlorination reaction. The reaction of HOCl with the active site Lys-79 generates a lysine chloramine, which plays a key role in directing regiospecific chlorination of substrate in this important class of biosynthetic enzymes. It is also able to use bromide ions to generate monobrominated Trp.<ref>PMID:10941070</ref> <ref>PMID:9172332</ref> <ref>PMID:9537395</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Tryptophan 7-halogenase]]
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[[Category: Levy, C W]]
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[[Category: Oxidoreductase]]

Revision as of 17:15, 20 January 2016

Crystal structure of Tryptophan 7-halogenase (PrnA) Mutant E450K

4z43, resolution 2.29Å

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