5es8

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'''Unreleased structure'''
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==Crystal structure of the initiation module of LgrA in the thiolation state==
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<StructureSection load='5es8' size='340' side='right' caption='[[5es8]], [[Resolution|resolution]] 2.55&Aring;' scene=''>
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The entry 5es8 is ON HOLD until Paper Publication
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== Structural highlights ==
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<table><tr><td colspan='2'>[[5es8]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5ES8 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5ES8 FirstGlance]. <br>
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Authors: Reimer, J.M., Aloise, M.N., Schmeing, T.M.
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=5S4:[(3~{R})-4-[[3-[2-[[(2~{S})-2-AZANYL-3-METHYL-BUTANOYL]AMINO]ETHYLAMINO]-3-OXIDANYLIDENE-PROPYL]AMINO]-2,2-DIMETHYL-3-OXIDANYL-4-OXIDANYLIDENE-BUTYL]+DIHYDROGEN+PHOSPHATE'>5S4</scene></td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5es5|5es5]], [[5es6|5es6]], [[5es7|5es7]], [[5es9|5es9]]</td></tr>
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Description: Crystal structure of the initiation module of LgrA in the thiolation state
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5es8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5es8 OCA], [http://pdbe.org/5es8 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5es8 RCSB], [http://www.ebi.ac.uk/pdbsum/5es8 PDBsum]</span></td></tr>
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[[Category: Unreleased Structures]]
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</table>
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[[Category: Aloise, M.N]]
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== Function ==
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[[Category: Reimer, J.M]]
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[[http://www.uniprot.org/uniprot/LGRA_BREPA LGRA_BREPA]] Activates valine (or leucine, but much less frequently), and then glycine and catalyzes the formation of the peptide bond in the first step of peptide synthesis. This enzyme may also play a role in N-formylation of the first amino acid residue in the synthesized dipeptide.
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[[Category: Schmeing, T.M]]
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__TOC__
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</StructureSection>
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[[Category: Aloise, M N]]
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[[Category: Reimer, J M]]
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[[Category: Schmeing, T M]]
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[[Category: Adenylation domain]]
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[[Category: Formylation domain]]
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[[Category: Ligase]]
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[[Category: Nrp]]
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[[Category: Peptidyl carrier protein]]

Revision as of 17:24, 20 January 2016

Crystal structure of the initiation module of LgrA in the thiolation state

5es8, resolution 2.55Å

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