5fir
From Proteopedia
(Difference between revisions)
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| - | + | ==Crystal structure of C. elegans XRN2 in complex with the XRN2-binding domain of PAXT-1== | |
| - | + | <StructureSection load='5fir' size='340' side='right' caption='[[5fir]], [[Resolution|resolution]] 2.84Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[5fir]] is a 12 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5FIR OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5FIR FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> | |
| - | + | <tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr> | |
| - | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5fir FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5fir OCA], [http://pdbe.org/5fir PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5fir RCSB], [http://www.ebi.ac.uk/pdbsum/5fir PDBsum]</span></td></tr> | |
| - | [[ | + | </table> |
| - | [[ | + | == Function == |
| + | [[http://www.uniprot.org/uniprot/XRN2_CAEEL XRN2_CAEEL]] Possesses 5'->3' exoribonuclease activity. Plays a role in maintenance of steady-state concentration and turnover of microRNAs (miRNA) by degradation of mature miRNA. Partially redundant to xrn-1 in miRNA guide strand degradation. Implicated in differential regulation of mRNAs such as let-7 by controlling the accumulation of mature miRNA. Positively regulates molting of the pharyngeal cuticle.<ref>PMID:19734881</ref> <ref>PMID:21397849</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
[[Category: Grosshans, H]] | [[Category: Grosshans, H]] | ||
| - | [[Category: | + | [[Category: Gut, H]] |
[[Category: Katic, I]] | [[Category: Katic, I]] | ||
| + | [[Category: Richter, H]] | ||
| + | [[Category: 5'-3' exoribonuclease]] | ||
| + | [[Category: Hydrolase]] | ||
| + | [[Category: Mirna turnover]] | ||
Revision as of 17:27, 20 January 2016
Crystal structure of C. elegans XRN2 in complex with the XRN2-binding domain of PAXT-1
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