5hem

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m (Protected "5hem" [edit=sysop:move=sysop])
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'''Unreleased structure'''
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==Crystal structure of the N-terminus D161Y bromodomain mutant of human BRD2==
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<StructureSection load='5hem' size='340' side='right' caption='[[5hem]], [[Resolution|resolution]] 1.65&Aring;' scene=''>
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The entry 5hem is ON HOLD
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== Structural highlights ==
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<table><tr><td colspan='2'>[[5hem]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5HEM OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5HEM FirstGlance]. <br>
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Authors: Tallant, C., Lori, C., Pasquo, A., Chiaraluce, R., Consalvi, V., Newman, J.A., von Delft, F., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Knapp, S.
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5hem FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5hem OCA], [http://pdbe.org/5hem PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5hem RCSB], [http://www.ebi.ac.uk/pdbsum/5hem PDBsum]</span></td></tr>
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Description: Crystal structure of the N-terminus D161Y bromodomain mutant of human BRD2
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</table>
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[[Category: Unreleased Structures]]
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== Function ==
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[[Category: Pasquo, A]]
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[[http://www.uniprot.org/uniprot/BRD2_HUMAN BRD2_HUMAN]] May play a role in spermatogenesis or folliculogenesis (By similarity). Binds hyperacetylated chromatin and plays a role in the regulation of transcription, probably by chromatin remodeling. Regulates transcription of the CCND1 gene. Plays a role in nucleosome assembly.<ref>PMID:18406326</ref>
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[[Category: Lori, C]]
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== References ==
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[[Category: Knapp, S]]
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<references/>
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[[Category: Chiaraluce, R]]
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__TOC__
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</StructureSection>
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[[Category: Arrowsmith, C H]]
[[Category: Bountra, C]]
[[Category: Bountra, C]]
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[[Category: Chiaraluce, R]]
[[Category: Consalvi, V]]
[[Category: Consalvi, V]]
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[[Category: Arrowsmith, C.H]]
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[[Category: Delft, F von]]
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[[Category: Von Delft, F]]
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[[Category: Edwards, A M]]
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[[Category: Edwards, A.M]]
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[[Category: Knapp, S]]
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[[Category: Newman, J.A]]
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[[Category: Lori, C]]
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[[Category: Newman, J A]]
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[[Category: Pasquo, A]]
[[Category: Tallant, C]]
[[Category: Tallant, C]]
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[[Category: Post translational modifications recognition]]
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[[Category: Transcription]]
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[[Category: Transcription regulation]]

Revision as of 17:28, 20 January 2016

Crystal structure of the N-terminus D161Y bromodomain mutant of human BRD2

5hem, resolution 1.65Å

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