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Exonuclease

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'''Exonucleases''' (ExN) cleave nucleotides at the end of a polynucleotide chain<ref>PMID:8747466</ref>. In ''E. coli'' there are ExN I to VIII.<br />
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'''Exonucleases''' (ExN) cleave nucleotides at the end of a polynucleotide chain<ref>PMID:14770007</ref>. In ''E. coli'' there are ExN I to VIII. ExN were found in human and yeast as well.
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* '''ExN-I''' cleaves single-stranded DNA.<br />
* '''ExN-I''' cleaves single-stranded DNA.<br />
* '''ExN-II''' is associated with DNA polymerase.<br />
* '''ExN-II''' is associated with DNA polymerase.<br />
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* '''ExN-V''' cleaves linear double-stranded DNA.<br />
* '''ExN-V''' cleaves linear double-stranded DNA.<br />
* '''ExN-VIII''' requires a free 5’ OH group for reacting.<br />
* '''ExN-VIII''' requires a free 5’ OH group for reacting.<br />
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* '''ExN''' were found in human and yeast as well.
 
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Revision as of 18:16, 20 January 2016

E. coli exonuclease I complex with phosphate, glycerol and Mg+2 ion (PDB code 1fxx)

Drag the structure with the mouse to rotate

3D Structures of exonuclease

Updated on 20-January-2016

References

  1. ↑ Mukherjee D, Fritz DT, Kilpatrick WJ, Gao M, Wilusz J. Analysis of RNA exonucleolytic activities in cellular extracts. Methods Mol Biol. 2004;257:193-212. PMID:14770007 doi:http://dx.doi.org/10.1385/1-59259-750-5:193

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Michal Harel, Alexander Berchansky, Joel L. Sussman

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