Exportin
From Proteopedia
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<StructureSection load='3icq' size='340' side='right' caption='Structure of yeast exportin-5 (dark green and dark red) complex with GTPaseRan (pale green and pink), Mg+2 (green) and RNA (PDB code [[3icq]]).' scene=''> | <StructureSection load='3icq' size='340' side='right' caption='Structure of yeast exportin-5 (dark green and dark red) complex with GTPaseRan (pale green and pink), Mg+2 (green) and RNA (PDB code [[3icq]]).' scene=''> | ||
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| - | == Function == | ||
'''Exportins''' (XPO) or '''chromosomal maintenance protein''' mediate the nuclear export of cellular proteins with a leucine-rich export signal (NES) and RNA. XPO is regulated by GTPaseRan. RanGTP bind to XPO forming a ternary complex with the exported protein. The complex diffuses through the nuclear core complex to the cytoplasm and then dissociates. '''XPO-t''' exports tRNA from the nucleus<ref>PMID:17786152</ref>. | '''Exportins''' (XPO) or '''chromosomal maintenance protein''' mediate the nuclear export of cellular proteins with a leucine-rich export signal (NES) and RNA. XPO is regulated by GTPaseRan. RanGTP bind to XPO forming a ternary complex with the exported protein. The complex diffuses through the nuclear core complex to the cytoplasm and then dissociates. '''XPO-t''' exports tRNA from the nucleus<ref>PMID:17786152</ref>. | ||
| - | == Disease == | ||
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| - | == Relevance == | ||
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| - | == Structural highlights == | ||
</StructureSection> | </StructureSection> | ||
Revision as of 19:55, 20 January 2016
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3D structures of exportin
Updated on 20-January-2016
References
- ↑ Kohler A, Hurt E. Exporting RNA from the nucleus to the cytoplasm. Nat Rev Mol Cell Biol. 2007 Oct;8(10):761-73. PMID:17786152 doi:http://dx.doi.org/10.1038/nrm2255
