This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.
Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.
Factor VIII
From Proteopedia
| Line 1: | Line 1: | ||
| - | {{STRUCTURE_2r7e| PDB=2r7e | SIZE=400| SCENE=Factor_VIII/Cv/1 |right|CAPTION=Glycosylated human Factor VIII. Residues 19-760 (grey) 1582-2351 (green) complex with Ca+2 (green) and Cu+2 (orange) ions, [[2r7e]] }} | ||
| - | [[Factor VIII]] (FVIII) is a blood clotting factor | + | <StructureSection load='2r7e' size='350' side='right' scene='' caption='Glycosylated human Factor VIII. Residues 19-760 (grey) 1582-2351 (green) complex with Ca+2 (green) and Cu+2 (orange) ions (PDB code [[2r7e]]) '> |
| + | == Function == | ||
| + | |||
| + | [[Factor VIII]] (FVIII) is a blood clotting factor. FVIII is a cofactor for [[Factor IX|factor IXa]]<ref>PMID:2491949</ref> . See also [[Factor VIII (Hebrew)]]. | ||
<!-- | <!-- | ||
| Line 7: | Line 9: | ||
The A subunit is composed of an activation peptide and 4 domains: the β-sandwich <scene name='1f13/Chaina_domain1/1'>domain</scene>, the central core domain, the barrel 1 domain, and the | The A subunit is composed of an activation peptide and 4 domains: the β-sandwich <scene name='1f13/Chaina_domain1/1'>domain</scene>, the central core domain, the barrel 1 domain, and the | ||
<scene name='1f13/Fxiii_4domains_colored/1'>barrel 2 domain</scene>.--> | <scene name='1f13/Fxiii_4domains_colored/1'>barrel 2 domain</scene>.--> | ||
| + | == Disease == | ||
| + | |||
| + | Defects in the protein result in hemophilia A. | ||
| + | |||
| + | == Relevance == | ||
| - | + | Factor VIII is given to hemophiliacs in order to restore homestasis. | |
<br /><br /> | <br /><br /> | ||
<br /> | <br /> | ||
<br /> | <br /> | ||
<br /> | <br /> | ||
| + | </StructureSection> | ||
== 3D Structures of Factor VIII == | == 3D Structures of Factor VIII == | ||
Revision as of 20:26, 20 January 2016
| |||||||||||
3D Structures of Factor VIII
Updated on 20-January-2016
2r7e, 3cdz, 3j2q, 4bdv – hFVIII – human
3hnb, 3hny, 3hob – hFVIII light chain C2 domain
1d7p - hFVIII light chain C2 domain (mutant)
1cfg, 1fac - hFVIII light chain C2 domain membrane-binding peptide - NMR
1iqd - hFVIII light chain C2 domain (mutant) + monoclonal Fab
4ki5 - mFVIII light chain C2 domain + monoclonal Fab – mouse
3j2s - hFVIII light chain
4mo3 - FVIII light chain C2 domain – pig
