Factor XIII
From Proteopedia
(Difference between revisions)
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{{STRUCTURE_1ggt| PDB=1ggt | SIZE=300| SCENE=Factor_XIII/Cv/1 |right|CAPTION=Human Factor XIII dimer, [[1ggt]] }} | {{STRUCTURE_1ggt| PDB=1ggt | SIZE=300| SCENE=Factor_XIII/Cv/1 |right|CAPTION=Human Factor XIII dimer, [[1ggt]] }} | ||
| - | [[Factor XIII]] (FXIII) belongs to the blood coagulation system and crosslinks fibrin resulting in an insoluble clot. FXIII is activated by thrombin which cleaves it and releases an activation peptide. | + | [[Factor XIII]] (FXIII) belongs to the blood coagulation system and crosslinks fibrin resulting in an insoluble clot. FXIII is activated by thrombin which cleaves it and releases an activation peptide<ref>PMID:17842715</ref>. |
== 3D Structures of Factor XIII == | == 3D Structures of Factor XIII == | ||
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[[4kty]] - hFXIII subunit A + peptide-like ligand<br /> | [[4kty]] - hFXIII subunit A + peptide-like ligand<br /> | ||
[[1ggy]], [[1qrk]], [[1ggu]], [[1evu]] – hFXIII + ion<br /> | [[1ggy]], [[1qrk]], [[1ggu]], [[1evu]] – hFXIII + ion<br /> | ||
| - | [[1de7]] – | + | [[1de7]] – hFXIII activation peptide + α-thrombin<br /> |
| + | == References == | ||
| + | <references/> | ||
[[Category:Topic Page]] | [[Category:Topic Page]] | ||
Revision as of 20:46, 20 January 2016
Factor XIII (FXIII) belongs to the blood coagulation system and crosslinks fibrin resulting in an insoluble clot. FXIII is activated by thrombin which cleaves it and releases an activation peptide[1].
3D Structures of Factor XIII
Updated on 20-January-2016
1ggt – hFXIII - human
1ex0 – hFXIII zymogen (mutant)
1fie – hFXIII subunit A
1f13 - hFXIII zymogen subunit A dimer
4kty - hFXIII subunit A + peptide-like ligand
1ggy, 1qrk, 1ggu, 1evu – hFXIII + ion
1de7 – hFXIII activation peptide + α-thrombin
References
- ↑ Laki K, Lorand L. On the Solubility of Fibrin Clots. Science. 1948 Sep 10;108(2802):280. PMID:17842715 doi:http://dx.doi.org/10.1126/science.108.2802.280
