Fibroblast growth factor
From Proteopedia
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| - | '''Fibroblast growth factors''' (FGF) are involved in angiogenesis, wound-healing and embryonic development. FGF is heparin-binding protein. FGF require heparan sulfate (HS) to activate the four FGF cell-surface receptors (FGFR). In vertebrates there are 23 members in the FGF family | + | <StructureSection load='2uus' size='350' side='right' scene='' caption='Rat fibroblast growth factor 1 complex with heparan sulfate (PDB code [[2uus]]) '> |
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| + | == Function == | ||
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| + | '''Fibroblast growth factors''' (FGF) are involved in angiogenesis, wound-healing and embryonic development. FGF is heparin-binding protein. FGF require heparan sulfate (HS) to activate the four FGF cell-surface receptors (FGFR). In vertebrates there are 23 members in the FGF family<ref>PMID:8747466</ref>. <br /> | ||
* '''FGF1''' is called acidic FGF.<br /> | * '''FGF1''' is called acidic FGF.<br /> | ||
* '''FGF2''' is called basic FGF.<br /> | * '''FGF2''' is called basic FGF.<br /> | ||
* '''FGF7''' is called keratinocyte growth factor which is present in the eiptheliazation-phase of wound healing when keratinocytes are covering the wound. | * '''FGF7''' is called keratinocyte growth factor which is present in the eiptheliazation-phase of wound healing when keratinocytes are covering the wound. | ||
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| + | == Relevance == | ||
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| + | FGF signaling is important in the pathogenesis of a variety of tumor types. | ||
| + | </StructureSection> | ||
==3D structures of fibroblast growth factor== | ==3D structures of fibroblast growth factor== | ||
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**[[2p39]] – hFGF23 <br /> | **[[2p39]] – hFGF23 <br /> | ||
}} | }} | ||
| + | == References == | ||
| + | <references/> | ||
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[[Category:Topic Page]] | [[Category:Topic Page]] | ||
Revision as of 22:25, 21 January 2016
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3D structures of fibroblast growth factor
Updated on 21-January-2016
