Fibroblast growth factor receptor
From Proteopedia
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<StructureSection load='1evt' size='350' side='right' scene='' caption='Human fibroblast growth factor receptor 1 ligand-binding domain modules D2 and D3 (pink and yellow) complex with fibroblast growth factor 1 (grey and green) and sulfate (PDB code [[1evt]]) '> | <StructureSection load='1evt' size='350' side='right' scene='' caption='Human fibroblast growth factor receptor 1 ligand-binding domain modules D2 and D3 (pink and yellow) complex with fibroblast growth factor 1 (grey and green) and sulfate (PDB code [[1evt]]) '> | ||
== Function == | == Function == | ||
| - | '''Fibroblast growth factor receptors''' (FGFR) are receptors which bind fibroblast growth factors (FGF). Each FGFR can activate several FGFs. Five FGFRs have been identified so far. FGFRs differ in their ligand specificity and tissue distribution. The binding of FGF to FGFR starts a cascade of signaling which influences mitogenesis and differentiation<ref>PMID: | + | '''Fibroblast growth factor receptors''' (FGFR) are receptors which bind fibroblast growth factors (FGF). Each FGFR can activate several FGFs. Five FGFRs have been identified so far. FGFRs differ in their ligand specificity and tissue distribution. The binding of FGF to FGFR starts a cascade of signaling which influences mitogenesis and differentiation<ref>PMID:8713482</ref>. |
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| + | == Disease == | ||
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| + | Mutation in FGFR3 causes achondroplasia and is involved in myeloma. Mutations in FGFR2 causes Crouzon syndrome. | ||
== Structural insights == | == Structural insights == | ||
Revision as of 23:01, 21 January 2016
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3D structures of fibroblast growth factor receptor
Updated on 21-January-2016
