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Flavin reductase
From Proteopedia
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| + | <StructureSection load='1he2' size='350' side='right' scene='' caption='Human flavin reductase complex with biliverdin IX α and NADP (PDB code [[1he2]]) '> | ||
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to a Jmol applet. Check out the other buttons as well! | to a Jmol applet. Check out the other buttons as well! | ||
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| - | '''Flavin reductase''' (FR) catalyzes the NADPH-dependent reduction of a variety of flavins such as riboflavin, FAD, FMN, biliverdin, methemoglobin and pyrroloquinoline quinone. FR converts reduced riboflavin to riboflavin and bilirubin to biliverdin. | + | == Function == |
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| + | '''Flavin reductase''' (FR) catalyzes the NADPH-dependent reduction of a variety of flavins such as riboflavin, FAD, FMN, biliverdin, methemoglobin and pyrroloquinoline quinone. FR converts reduced riboflavin to riboflavin and bilirubin to biliverdin. FR is involved in heme catabolism<ref>PMID:7400118</ref> . | ||
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| + | == Relevance == | ||
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| + | FR catalytic reaction is the basis of the therapeutic use of methylene blue or riboflavin in the treatment of methemoglobinemia. Bacterial FR are used to sensitize tumors to drugs. | ||
| + | </StructureSection> | ||
==3D structures of flavin reductase== | ==3D structures of flavin reductase== | ||
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[[1rz1]] - GtFR + FAD + NAD<br /> | [[1rz1]] - GtFR + FAD + NAD<br /> | ||
[[3pft]] - FR (mutant) + FMN – ''Mycobacterium goodii'' | [[3pft]] - FR (mutant) + FMN – ''Mycobacterium goodii'' | ||
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| + | == References == | ||
| + | <references/> | ||
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[[Category:Topic Page]] | [[Category:Topic Page]] | ||
Revision as of 16:13, 22 January 2016
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3D structures of flavin reductase
Updated on 22-January-2016
1qfj – FR – Escherichia coli
1bkj – VhFR + FMN – Vibrio harveyi
2bkj - VhFR + NAD + FMN
1hdo - hFR + NADP - human
1he2 - hFR + biliverdin IX α + NADP
1he3 - hFR + mesobiliverdin IV α + NADP
1he4 - hFR + FMN + NADP
1he5 - hFR + lumichrome + NADP
1rz0 – GtFR + FAD – Geobacillus thermoglucosidasius
1rz1 - GtFR + FAD + NAD
3pft - FR (mutant) + FMN – Mycobacterium goodii
References
- ↑ Yubisui T, Takeshita M, Yoneyama Y. Reduction of methemoglobin through flavin at the physiological concentration by NADPH-flavin reductase of human erythrocytes. J Biochem. 1980 Jun;87(6):1715-20. PMID:7400118
