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Focal adhesion kinase

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For details on '''focal adhesion kinase or protein tyrosine kinase 2β (PTK2)''' see [[Molecular Playground/FAK]]<ref>PMID:15688067</ref>.
For details on '''focal adhesion kinase or protein tyrosine kinase 2β (PTK2)''' see [[Molecular Playground/FAK]]<ref>PMID:15688067</ref>.
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== Relevance ==
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FAX is overexpressed in many tumor cells. Hence they are investigated as anti-tumor drug targets<ref>PMID:22075057</ref>.
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</StructureSection>
</StructureSection>
== 3D Structures of focal adhesion kinase ==
== 3D Structures of focal adhesion kinase ==

Revision as of 18:38, 22 January 2016

Focal adhesion kinase 1 kinase domain complex with pyrimidine derivative inhibitor and sulfate (PDB code 2jkk)

Drag the structure with the mouse to rotate

3D Structures of focal adhesion kinase

Updated on 22-January-2016

References

  1. ↑ Mitra SK, Hanson DA, Schlaepfer DD. Focal adhesion kinase: in command and control of cell motility. Nat Rev Mol Cell Biol. 2005 Jan;6(1):56-68. PMID:15688067 doi:http://dx.doi.org/10.1038/nrm1549
  2. ↑ Cabrita MA, Jones LM, Quizi JL, Sabourin LA, McKay BC, Addison CL. Focal adhesion kinase inhibitors are potent anti-angiogenic agents. Mol Oncol. 2011 Dec;5(6):517-26. doi: 10.1016/j.molonc.2011.10.004. Epub 2011 Oct, 20. PMID:22075057 doi:http://dx.doi.org/10.1016/j.molonc.2011.10.004

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Michal Harel, Alexander Berchansky

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