Focal adhesion kinase
From Proteopedia
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== Relevance == | == Relevance == | ||
| - | + | FAK is overexpressed in many tumor cells. Hence they are investigated as anti-tumor drug targets<ref>PMID:22075057</ref>. | |
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| + | == Structural insights == | ||
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| + | FAK ATP-binding site is the location of inhibitor binding. | ||
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</StructureSection> | </StructureSection> | ||
== 3D Structures of focal adhesion kinase == | == 3D Structures of focal adhesion kinase == | ||
Revision as of 18:50, 22 January 2016
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3D Structures of focal adhesion kinase
Updated on 22-January-2016
References
- ↑ Mitra SK, Hanson DA, Schlaepfer DD. Focal adhesion kinase: in command and control of cell motility. Nat Rev Mol Cell Biol. 2005 Jan;6(1):56-68. PMID:15688067 doi:http://dx.doi.org/10.1038/nrm1549
- ↑ Cabrita MA, Jones LM, Quizi JL, Sabourin LA, McKay BC, Addison CL. Focal adhesion kinase inhibitors are potent anti-angiogenic agents. Mol Oncol. 2011 Dec;5(6):517-26. doi: 10.1016/j.molonc.2011.10.004. Epub 2011 Oct, 20. PMID:22075057 doi:http://dx.doi.org/10.1016/j.molonc.2011.10.004
