Farnesyl diphosphate synthase

(Difference between revisions)

Revision as of 12:10, 24 January 2016

Human farnesyl diphosphate synthase complex with lipophylic bisphosphonate inhibitor and Mg+2 ions (green) (PDB code 2opm)

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Updated on 24-January-2016

↑ Schulbach MC, Mahapatra S, Macchia M, Barontini S, Papi C, Minutolo F, Bertini S, Brennan PJ, Crick DC. Purification, enzymatic characterization, and inhibition of the Z-farnesyl diphosphate synthase from Mycobacterium tuberculosis. J Biol Chem. 2001 Apr 13;276(15):11624-30. Epub 2001 Jan 4. PMID:11152452 doi:http://dx.doi.org/10.1074/jbc.M007168200
↑ Das S, Edwards PA, Crockett JC, Rogers MJ. Upregulation of endogenous farnesyl diphosphate synthase overcomes the inhibitory effect of bisphosphonate on protein prenylation in Hela cells. Biochim Biophys Acta. 2014 Apr 4;1841(4):569-73. doi:, 10.1016/j.bbalip.2013.12.010. Epub 2013 Dec 22. PMID:24369118 doi:http://dx.doi.org/10.1016/j.bbalip.2013.12.010

@@ Line 1: / Line 1: @@
-<StructureSection load='2opm' size='350' side='right' scene='48/485622/Cv/1' caption='Human farnesyl diphosphate synthase complex with  lipophylic bisphosphonate inhibitor and Mg+2 ions (green) (PDB code [[2opm]]) '>
+<StructureSection load='2opm' size='450' side='right' scene='48/485622/Cv/1' caption='Human farnesyl diphosphate synthase complex with  lipophylic bisphosphonate inhibitor and Mg+2 ions (green) (PDB code [[2opm]]) '>
 == Function ==
@@ Line 11: / Line 11: @@
 == Structural insights ==
-FPS active site contains Mg<sup>+2</sup> ions and binds bisphosphonate inhibitors.
+FPS <scene name='48/485622/Cv/8'>active site</scene> contains <scene name='48/485622/Cv/9'>Mg+2 ions coordination sites</scene> and binds bisphosphonate inhibitors.
 </StructureSection>
 ==3D structures of farnesyl diphosphate synthase==