Focal adhesion kinase
From Proteopedia
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| - | <StructureSection load='2jkk' size='350' side='right' scene='' caption='Focal adhesion kinase 1 kinase domain complex with pyrimidine derivative inhibitor and sulfate (PDB code [[2jkk]]) '> | + | <StructureSection load='2jkk' size='350' side='right' scene='48/480805/Cv/1' caption='Focal adhesion kinase 1 kinase domain complex with pyrimidine derivative inhibitor and sulfate (PDB code [[2jkk]]) '> |
For details on '''focal adhesion kinase or protein tyrosine kinase 2β (PTK2)''' see [[Molecular Playground/FAK]]<ref>PMID:15688067</ref>. | For details on '''focal adhesion kinase or protein tyrosine kinase 2β (PTK2)''' see [[Molecular Playground/FAK]]<ref>PMID:15688067</ref>. | ||
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== Structural insights == | == Structural insights == | ||
| - | FAK ATP-binding site is the location of inhibitor binding<ref>PMID:19030106</ref>. | + | FAK ATP-binding site is the <scene name='48/480805/Cv/4'>location of inhibitor binding</scene><ref>PMID:19030106</ref>. |
Revision as of 12:22, 26 January 2016
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3D Structures of focal adhesion kinase
Updated on 26-January-2016
References
- ↑ Mitra SK, Hanson DA, Schlaepfer DD. Focal adhesion kinase: in command and control of cell motility. Nat Rev Mol Cell Biol. 2005 Jan;6(1):56-68. PMID:15688067 doi:http://dx.doi.org/10.1038/nrm1549
- ↑ Cabrita MA, Jones LM, Quizi JL, Sabourin LA, McKay BC, Addison CL. Focal adhesion kinase inhibitors are potent anti-angiogenic agents. Mol Oncol. 2011 Dec;5(6):517-26. doi: 10.1016/j.molonc.2011.10.004. Epub 2011 Oct, 20. PMID:22075057 doi:http://dx.doi.org/10.1016/j.molonc.2011.10.004
- ↑ Lietha D, Eck MJ. Crystal structures of the FAK kinase in complex with TAE226 and related bis-anilino pyrimidine inhibitors reveal a helical DFG conformation. PLoS ONE. 2008;3(11):e3800. Epub 2008 Nov 24. PMID:19030106 doi:10.1371/journal.pone.0003800
