Monocyte chemoattractant protein
From Proteopedia
(Difference between revisions)
Line 11: | Line 11: | ||
- GDCF-2 | - GDCF-2 | ||
- HC11. | - HC11. | ||
+ | |||
+ | Monomer or homodimer; in equilibrium. Binds to CCR2 and CCR4. Is tethered on endothelial cells by glycosaminoglycan (GAG) side chains of proteoglycans. | ||
+ | == Ligands == | ||
+ | K and PO4 | ||
== Disease == | == Disease == | ||
Line 23: | Line 27: | ||
CCL2 is part of the C-C motif group because of the covalent bond made between <scene name='72/721520/Cv/4'>2 of the 4 cysteines of the N terminal domain</scene>.<ref>PMID:8989326</ref> | CCL2 is part of the C-C motif group because of the covalent bond made between <scene name='72/721520/Cv/4'>2 of the 4 cysteines of the N terminal domain</scene>.<ref>PMID:8989326</ref> | ||
- | + | Post translational modifications at the N-terminus can regulate receptor and target cell selectivity. Deletion of the N-terminal residue converts it from an activator of basophil to an eosinophil chemoattractant. | |
</StructureSection> | </StructureSection> | ||
Line 58: | Line 62: | ||
http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/GetPage.pl?pdbcode=1DOK | http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/GetPage.pl?pdbcode=1DOK | ||
http://www.uniprot.org/uniprot/P13500#interaction | http://www.uniprot.org/uniprot/P13500#interaction | ||
+ | http://www.rcsb.org/pdb/explore/explore.do?structureId=3IFD | ||
<references/> | <references/> |
Revision as of 12:31, 26 January 2016
|
3D structures of Monocyte chemoattractant protein
Updated on 26-January-2016
References
https://fr.wikipedia.org/wiki/CCL2 http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/GetPage.pl?pdbcode=1DOK http://www.uniprot.org/uniprot/P13500#interaction http://www.rcsb.org/pdb/explore/explore.do?structureId=3IFD
- ↑ Carr MW, Roth SJ, Luther E, Rose SS, Springer TA. Monocyte chemoattractant protein 1 acts as a T-lymphocyte chemoattractant. Proc Natl Acad Sci U S A. 1994 Apr 26;91(9):3652-6. PMID:8170963
- ↑ Lubkowski J, Bujacz G, Boque L, Domaille PJ, Handel TM, Wlodawer A. The structure of MCP-1 in two crystal forms provides a rare example of variable quaternary interactions. Nat Struct Biol. 1997 Jan;4(1):64-9. PMID:8989326
Proteopedia Page Contributors and Editors (what is this?)
Coline Perrin, Alexane Caignard, Michal Harel, Alexander Berchansky, Joel L. Sussman