This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.
Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.
Monocyte chemoattractant protein
From Proteopedia
| Line 1: | Line 1: | ||
| - | <StructureSection load='1dok' size='350' side='right' caption='Monocyte chemoattractant protein 1 complex with sulfate (PDB code [[ | + | <StructureSection load='1dok' size='350' side='right' caption='Monocyte chemoattractant protein 1 complex with sulfate (PDB code [[13idf]])' scene='72/721520/Cv/2'> |
== Function == | == Function == | ||
| Line 12: | Line 12: | ||
- HC11. | - HC11. | ||
| - | + | It exists as a monomer or a dimer, eventhough the homodimer form is preferred. | |
| + | -> Binds to CCR2 and CCR4. Is tethered on endothelial cells by glycosaminoglycan (GAG) side chains of proteoglycans. | ||
== Ligands == | == Ligands == | ||
K and PO4 | K and PO4 | ||
Revision as of 12:41, 26 January 2016
| |||||||||||
3D structures of Monocyte chemoattractant protein
Updated on 26-January-2016
References
https://fr.wikipedia.org/wiki/CCL2 http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/GetPage.pl?pdbcode=1DOK http://www.uniprot.org/uniprot/P13500#interaction http://www.rcsb.org/pdb/explore/explore.do?structureId=3IFD
- ↑ Carr MW, Roth SJ, Luther E, Rose SS, Springer TA. Monocyte chemoattractant protein 1 acts as a T-lymphocyte chemoattractant. Proc Natl Acad Sci U S A. 1994 Apr 26;91(9):3652-6. PMID:8170963
- ↑ Lubkowski J, Bujacz G, Boque L, Domaille PJ, Handel TM, Wlodawer A. The structure of MCP-1 in two crystal forms provides a rare example of variable quaternary interactions. Nat Struct Biol. 1997 Jan;4(1):64-9. PMID:8989326
Proteopedia Page Contributors and Editors (what is this?)
Coline Perrin, Alexane Caignard, Michal Harel, Alexander Berchansky, Joel L. Sussman
