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(Difference between revisions)
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== Structure == | == Structure == | ||
| + | === ? === | ||
| + | Thanks to X-ray crystallography, the structure of 2OY4 has been solved with 1,7 Å resolution. This enzyme consists of <<scene name='71/719866/Helixes/1'>four alpha helixes</scene> and five beta sheets organized like as you can see on the J-mol figure. | ||
| + | |||
=== Pocket interaction === | === Pocket interaction === | ||
==== Ca2+ ==== | ==== Ca2+ ==== | ||
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== Function == | == Function == | ||
| + | The MMPs are secreted as inactive proproteins and then activated after a cleavage by extracellular proteinases. | ||
== Disease == | == Disease == | ||
Revision as of 20:10, 26 January 2016
MMP8
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References
- ↑ "MMP8 matrix metallopeptidase 8 (neutrophil collagenase)"
- ↑ Stams T, Spurlino JC, Smith DL, Wahl RC, Ho TF, Qoronfleh MW, Banks TM, Rubin B. Structure of human neutrophil collagenase reveals large S1' specificity pocket. Nat Struct Biol. 1994 Feb;1(2):119-23. PMID:7656015
