Calcium uptake protein 1
From Proteopedia
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==Your Heading Here (maybe something like 'Structure')== | ==Your Heading Here (maybe something like 'Structure')== | ||
<StructureSection load='4NSC' size='340' side='right' caption='Caption for this structure' scene=''> | <StructureSection load='4NSC' size='340' side='right' caption='Caption for this structure' scene=''> | ||
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Micu 1 (Mitochondrial Calcium Uptake 1) is a key regulator of mitochondrial calcium uniporter (MCU) required to increase calcium uptake by MCU when cytoplasmic calcium is high. | Micu 1 (Mitochondrial Calcium Uptake 1) is a key regulator of mitochondrial calcium uniporter (MCU) required to increase calcium uptake by MCU when cytoplasmic calcium is high. | ||
It also regulates glucose-dependent insulin secretion in pancreatic beta-cells by regulating mitochondrial calcium uptake. | It also regulates glucose-dependent insulin secretion in pancreatic beta-cells by regulating mitochondrial calcium uptake. | ||
== Function == | == Function == | ||
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Micu 1 is a regulator of Ca 2+ uptakes in mitochondria. | Micu 1 is a regulator of Ca 2+ uptakes in mitochondria. | ||
It mainly acts on MCU when linked to MICU2 (paralogues). | It mainly acts on MCU when linked to MICU2 (paralogues). | ||
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== Disease == | == Disease == | ||
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The major disease linked to a dysfunctional Micu 1 protein is myopathy with extrapyramidal signs (MPXPS). | The major disease linked to a dysfunctional Micu 1 protein is myopathy with extrapyramidal signs (MPXPS). | ||
But other diseases can be observed like : ataxia, microcephaly, ophthalmoplegia, ptosis, optic atrophy and axonal peripheral neuropathy | But other diseases can be observed like : ataxia, microcephaly, ophthalmoplegia, ptosis, optic atrophy and axonal peripheral neuropathy | ||
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== Structural highlights == | == Structural highlights == | ||
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Ca 2+ binds to EF domain on MICU 1 and 2 | Ca 2+ binds to EF domain on MICU 1 and 2 | ||
Revision as of 16:29, 27 January 2016
Your Heading Here (maybe something like 'Structure')
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