1bvj
From Proteopedia
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|PDB= 1bvj |SIZE=350|CAPTION= <scene name='initialview01'>1bvj</scene> | |PDB= 1bvj |SIZE=350|CAPTION= <scene name='initialview01'>1bvj</scene> | ||
|SITE= | |SITE= | ||
| - | |LIGAND= | + | |LIGAND= <scene name='pdbligand=A:ADENOSINE-5'-MONOPHOSPHATE'>A</scene>, <scene name='pdbligand=C:CYTIDINE-5'-MONOPHOSPHATE'>C</scene>, <scene name='pdbligand=G:GUANOSINE-5'-MONOPHOSPHATE'>G</scene>, <scene name='pdbligand=U:URIDINE-5'-MONOPHOSPHATE'>U</scene> |
|ACTIVITY= | |ACTIVITY= | ||
|GENE= | |GENE= | ||
| + | |DOMAIN= | ||
| + | |RELATEDENTRY= | ||
| + | |RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1bvj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1bvj OCA], [http://www.ebi.ac.uk/pdbsum/1bvj PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1bvj RCSB]</span> | ||
}} | }} | ||
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==About this Structure== | ==About this Structure== | ||
| - | 1BVJ is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/ | + | 1BVJ is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Human_immunodeficiency_virus_1 Human immunodeficiency virus 1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1BVJ OCA]. |
==Reference== | ==Reference== | ||
HIV-1 A-rich RNA loop mimics the tRNA anticodon structure., Puglisi EV, Puglisi JD, Nat Struct Biol. 1998 Dec;5(12):1033-6. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/9846871 9846871] | HIV-1 A-rich RNA loop mimics the tRNA anticodon structure., Puglisi EV, Puglisi JD, Nat Struct Biol. 1998 Dec;5(12):1033-6. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/9846871 9846871] | ||
| - | [[Category: | + | [[Category: Human immunodeficiency virus 1]] |
[[Category: Single protein]] | [[Category: Single protein]] | ||
[[Category: Puglisi, E V.]] | [[Category: Puglisi, E V.]] | ||
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[[Category: rna hairpin loop]] | [[Category: rna hairpin loop]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 19:09:08 2008'' |
Revision as of 16:09, 30 March 2008
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| Ligands: | , , , | ||||||
| Resources: | FirstGlance, OCA, PDBsum, RCSB | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
HIV-1 RNA A-RICH HAIRPIN LOOP
Overview
Interaction of HIV-1 genomic RNA and human tRNA(Lys)3 initiates viral reverse transcription. An adenosine-rich (A-rich) loop in HIV RNA mediates complex formation between tRNA and viral RNA. We have determined the structure of an A-rich loop oligonucleotide using nuclear magnetic resonance spectroscopy. The loop structure is stabilized by a noncanonical G-A pair and a U-turn motif, which leads to stacking of the conserved adenosines. The structure has similarity to the tRNA anticodon structure, and suggests possible mechanisms for its role in initiation of reverse transcription.
About this Structure
1BVJ is a Single protein structure of sequence from Human immunodeficiency virus 1. Full crystallographic information is available from OCA.
Reference
HIV-1 A-rich RNA loop mimics the tRNA anticodon structure., Puglisi EV, Puglisi JD, Nat Struct Biol. 1998 Dec;5(12):1033-6. PMID:9846871
Page seeded by OCA on Sun Mar 30 19:09:08 2008
