2rvj

(Difference between revisions)

Revision as of 18:43, 27 January 2016

@@ Line 1: / Line 1: @@
-==pET22-hESRP1-RRM3==
+==NMR structure of Epithelial splicing regulatory protein 1==
 <StructureSection load='2rvj' size='340' side='right' caption='[[2rvj]], [[NMR_Ensembles_of_Models | 15 NMR models]]' scene=''>
 == Structural highlights ==
@@ Line 5: / Line 5: @@
 </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2rvj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2rvj OCA], [http://pdbe.org/2rvj PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2rvj RCSB], [http://www.ebi.ac.uk/pdbsum/2rvj PDBsum]</span></td></tr>
 </table>
+== Function ==
+[[http://www.uniprot.org/uniprot/ESRP1_HUMAN ESRP1_HUMAN]] mRNA splicing factor that regulates the formation of epithelial cell-specific isoforms. Specifically regulates the expression of FGFR2-IIIb, an epithelial cell-specific isoform of FGFR2. Also regulates the splicing of CD44, CTNND1, ENAH, 3 transcripts that undergo changes in splicing during the epithelial-to-mesenchymal transition (EMT). Acts by directly binding specific sequences in mRNAs. Binds the GU-rich sequence motifs in the ISE/ISS-3, a cis-element regulatory region present in the mRNA of FGFR2.
 __TOC__
 </StructureSection>