1bxt
From Proteopedia
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| + | |RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1bxt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1bxt OCA], [http://www.ebi.ac.uk/pdbsum/1bxt PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1bxt RCSB]</span> | ||
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[[Category: toxic shock-like syndrome]] | [[Category: toxic shock-like syndrome]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 19:10:28 2008'' |
Revision as of 16:10, 30 March 2008
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| , resolution 1.85Å | |||||||
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| Resources: | FirstGlance, OCA, PDBsum, RCSB | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
STREPTOCOCCAL SUPERANTIGEN (SSA) FROM STREPTOCOCCUS PYOGENES
Overview
Streptococcal superantigen (SSA) is a 28,000 Mr toxin originally isolated from a pathogenic strain of Streptococcus pyogenes that has 60% sequence identity with staphylococcal enterotoxin B (SEB). SSA and SEB, however, do not compete for binding on the surfaces of cells expressing MHC class II molecules. This behavior had been ascribed to SSA and SEB binding to distinct sites on, or different subsets of, HLA-DR molecules. Here we demonstrate that SSA binds predominantly to HLA-DQ, rather than to HLA-DR molecules, and present the crystal structure of SSA at 1.85 A resolution. These data provide a structural basis for interpreting the interaction of SSA with HLA-DQ molecules as well as a foundation for understanding bacterial superantigen affinities for distinct MHC isotypes.
About this Structure
1BXT is a Single protein structure of sequence from Streptococcus pyogenes. Full crystallographic information is available from OCA.
Reference
Structural basis for HLA-DQ binding by the streptococcal superantigen SSA., Sundberg E, Jardetzky TS, Nat Struct Biol. 1999 Feb;6(2):123-9. PMID:10048922
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