2n0w
From Proteopedia
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| - | ''' | + | ==Mdmx-SJ212== |
| - | + | <StructureSection load='2n0w' size='340' side='right' caption='[[2n0w]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[2n0w]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2N0W OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2N0W FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=48L:4-({(4S,5R)-4-(5-BROMO-2-FLUOROPHENYL)-5-(4-CHLOROPHENYL)-2-[4-METHOXY-2-(PROPAN-2-YLOXY)PHENYL]-4,5-DIHYDRO-1H-IMIDAZOL-1-YL}CARBONYL)PIPERAZIN-2-ONE'>48L</scene></td></tr> | |
| - | + | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2n0u|2n0u]], [[2n14|2n14]], [[2n06|2n06]]</td></tr> | |
| - | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2n0w FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2n0w OCA], [http://pdbe.org/2n0w PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2n0w RCSB], [http://www.ebi.ac.uk/pdbsum/2n0w PDBsum]</span></td></tr> | |
| - | [[Category: | + | </table> |
| - | [[Category: Kriwacki, R | + | == Function == |
| - | [[Category: | + | [[http://www.uniprot.org/uniprot/MDM4_HUMAN MDM4_HUMAN]] Inhibits p53/TP53- and TP73/p73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain. Inhibits degradation of MDM2. Can reverse MDM2-targeted degradation of TP53 while maintaining suppression of TP53 transactivation and apoptotic functions.<ref>PMID:16163388</ref> <ref>PMID:16511572</ref> |
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Grace, C R]] | ||
| + | [[Category: Kriwacki, R W]] | ||
| + | [[Category: Mdmx]] | ||
| + | [[Category: Negative regulators of p53]] | ||
| + | [[Category: Signaling protein]] | ||
Revision as of 02:24, 28 January 2016
Mdmx-SJ212
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