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2na7

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'''Unreleased structure'''
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==Transmembrane domain of human Fas/CD95 death receptor==
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<StructureSection load='2na7' size='340' side='right' caption='[[2na7]], [[NMR_Ensembles_of_Models | 15 NMR models]]' scene=''>
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The entry 2na7 is ON HOLD
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== Structural highlights ==
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<table><tr><td colspan='2'>[[2na7]] is a 3 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2NA7 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2NA7 FirstGlance]. <br>
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Authors: Fu, Q., Chou, J.J., Membrane Protein Structures by Solution NMR (MPSbyNMR)
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</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2na6|2na6]]</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2na7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2na7 OCA], [http://pdbe.org/2na7 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2na7 RCSB], [http://www.ebi.ac.uk/pdbsum/2na7 PDBsum]</span></td></tr>
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Description: Transmembrane domain of human Fas/CD95 death receptor
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</table>
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[[Category: Unreleased Structures]]
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== Disease ==
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[[http://www.uniprot.org/uniprot/TNR6_HUMAN TNR6_HUMAN]] Defects in FAS are the cause of autoimmune lymphoproliferative syndrome type 1A (ALPS1A) [MIM:[http://omim.org/entry/601859 601859]]; also known as Canale-Smith syndrome (CSS). ALPS is a childhood syndrome involving hemolytic anemia and thrombocytopenia with massive lymphadenopathy and splenomegaly.<ref>PMID:17336828</ref> <ref>PMID:7540117</ref> <ref>PMID:8929361</ref> <ref>PMID:9028321</ref> <ref>PMID:9028957</ref> <ref>PMID:9322534</ref> <ref>PMID:9821419</ref> <ref>PMID:10090885</ref> <ref>PMID:10515860</ref> <ref>PMID:10340403</ref> <ref>PMID:9927496</ref> <ref>PMID:11418480</ref> <ref>PMID:20935634</ref>
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== Function ==
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[[http://www.uniprot.org/uniprot/TNR6_HUMAN TNR6_HUMAN]] Receptor for TNFSF6/FASLG. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. FAS-mediated apoptosis may have a role in the induction of peripheral tolerance, in the antigen-stimulated suicide of mature T-cells, or both. The secreted isoforms 2 to 6 block apoptosis (in vitro).<ref>PMID:7533181</ref> <ref>PMID:19118384</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Chou, J J]]
[[Category: Fu, Q]]
[[Category: Fu, Q]]
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[[Category: Membrane Protein Structures By Solution Nmr (Mpsbynmr)]]
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[[Category: MPSbyNMR, Membrane Protein Structures by Solution NMR]]
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[[Category: Chou, J.J]]
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[[Category: Apoptosis]]
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[[Category: Proline-containing motif]]
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[[Category: Transmembrane domain]]
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[[Category: Transmembrane helix trimer]]

Revision as of 02:24, 28 January 2016

Transmembrane domain of human Fas/CD95 death receptor

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