This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


4u6p

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
-
'''Unreleased structure'''
+
==Structural mechanism of error-free bypass of major benzo[a]pyrene adduct by human polymerase kappa==
-
 
+
<StructureSection load='4u6p' size='340' side='right' caption='[[4u6p]], [[Resolution|resolution]] 2.59&Aring;' scene=''>
-
The entry 4u6p is ON HOLD
+
== Structural highlights ==
-
 
+
<table><tr><td colspan='2'>[[4u6p]] is a 6 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4U6P OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4U6P FirstGlance]. <br>
-
Authors: Jha, V.K., Ling, H.
+
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=DCT:2,3-DIDEOXYCYTIDINE+5-TRIPHOSPHATE'>DCT</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=PGE:TRIETHYLENE+GLYCOL'>PGE</scene></td></tr>
-
 
+
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4u7c|4u7c]]</td></tr>
-
Description: Structural mechanism of error-free bypass of major benzo[a]pyrene adduct by human polymerase kappa
+
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/DNA-directed_DNA_polymerase DNA-directed DNA polymerase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.7.7 2.7.7.7] </span></td></tr>
-
[[Category: Unreleased Structures]]
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4u6p FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4u6p OCA], [http://pdbe.org/4u6p PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4u6p RCSB], [http://www.ebi.ac.uk/pdbsum/4u6p PDBsum]</span></td></tr>
-
[[Category: Jha, V.K]]
+
</table>
 +
== Function ==
 +
[[http://www.uniprot.org/uniprot/POLK_HUMAN POLK_HUMAN]] DNA polymerase specifically involved in DNA repair. Plays an important role in translesion synthesis, where the normal high-fidelity DNA polymerases cannot proceed and DNA synthesis stalls. Depending on the context, it inserts the correct base, but causes frequent base transitions, transversions and frameshifts. Lacks 3'-5' proofreading exonuclease activity. Forms a Schiff base with 5'-deoxyribose phosphate at abasic sites, but does not have lyase activity.<ref>PMID:10620008</ref> <ref>PMID:11024016</ref> <ref>PMID:12145297</ref> <ref>PMID:12444249</ref> <ref>PMID:12952891</ref> <ref>PMID:14630940</ref> <ref>PMID:15533436</ref>
 +
== References ==
 +
<references/>
 +
__TOC__
 +
</StructureSection>
 +
[[Category: DNA-directed DNA polymerase]]
 +
[[Category: Jha, V K]]
[[Category: Ling, H]]
[[Category: Ling, H]]
 +
[[Category: Dna damage tolerance]]
 +
[[Category: Dna replication]]
 +
[[Category: Environment pollution]]
 +
[[Category: Polymerase kappa]]
 +
[[Category: Transferase-dna complex]]

Revision as of 02:26, 28 January 2016

Structural mechanism of error-free bypass of major benzo[a]pyrene adduct by human polymerase kappa

4u6p, resolution 2.59Å

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/4u6p"
Personal tools